The Blockade of Transmembrane Cl- Flux Mitigates I/R-Induced Heart Injury via the Inhibition of Calpain Activity

The Blockade of Transmembrane Cl- Flux Mitigates I/R-Induced Heart Injury via the Inhibition of Calpain Activity

Aims: The aim of this study was to determine whether calpain is involved in Cl- -induced myocardial ischemia/reperfusion (I/R) injury. Methods: Isolated rat hearts were subjected to either 45 min of global no-flow ischemia followed by reperfusion or successive perfusion with Ca2+ -free KH solution f...

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Bibliographic Details
Main Authors: Jian-Ying Zhang, Feng Wu, Xiao-Ming Gu, Zhen-Xiao Jin, Ling-Heng Kong, Yuan Zhang, Jing-Jun Zhou, Feng Gao
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2015-04-01
Series:Cellular Physiology and Biochemistry
Subjects:
Chloride
Calpain
Heart
Calcium
Ischemia/Reperfusion
Online Access:http://www.karger.com/Article/FullText/374018

Internet

http://www.karger.com/Article/FullText/374018

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