Mitophagy: An Emerging Role in Aging and Age-Associated Diseases
Mitochondrial dysfunction constitutes one of the hallmarks of aging and is characterized by irregular mitochondrial morphology, insufficient ATP production, accumulation of mitochondrial DNA (mtDNA) mutations, increased production of mitochondrial reactive oxygen species (ROS) and the consequent oxi...
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doaj-cf7143b1640d45e4ae57197b8d27d1032020-11-25T02:56:30ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2020-03-01810.3389/fcell.2020.00200527573Mitophagy: An Emerging Role in Aging and Age-Associated DiseasesGuo Chen0Guido Kroemer1Guido Kroemer2Guido Kroemer3Guido Kroemer4Guido Kroemer5Guido Kroemer6Guido Kroemer7Guido Kroemer8Guido Kroemer9Guido Kroemer10Oliver Kepp11Oliver Kepp12Oliver Kepp13Oliver Kepp14Oliver Kepp15Oliver Kepp16Oliver Kepp17The State Key Laboratory of Medicinal Chemical Biology, College of Life Sciences, Nankai University, Tianjin, ChinaGustave Roussy Cancer Campus, Villejuif, FranceINSERM, UMR 1138, Centre de Recherche des Cordeliers, Paris, FranceEquipe 11 Labellisée par la Ligue Nationale Contre le Cancer, Centre de Recherche des Cordeliers, Paris, FranceUniversité de Paris, Paris, FranceMetabolomics and Cell Biology Platforms, Gustave Roussy Cancer Campus, Villejuif, FranceSorbonne Université, Paris, FranceUniversité Paris-Saclay, Faculté de Médecine, Kremlin-Bicêtre, FrancePôle de Biologie, Hôpital Européen Georges Pompidou, AP-HP, Paris, France0Suzhou Institute for Systems Medicine, Chinese Academy of Sciences, Suzhou, China1Karolinska Institute, Department of Women’s and Children’s Health, Karolinska University Hospital, Stockholm, SwedenGustave Roussy Cancer Campus, Villejuif, FranceINSERM, UMR 1138, Centre de Recherche des Cordeliers, Paris, FranceEquipe 11 Labellisée par la Ligue Nationale Contre le Cancer, Centre de Recherche des Cordeliers, Paris, FranceUniversité de Paris, Paris, FranceMetabolomics and Cell Biology Platforms, Gustave Roussy Cancer Campus, Villejuif, FranceSorbonne Université, Paris, FranceUniversité Paris-Saclay, Faculté de Médecine, Kremlin-Bicêtre, FranceMitochondrial dysfunction constitutes one of the hallmarks of aging and is characterized by irregular mitochondrial morphology, insufficient ATP production, accumulation of mitochondrial DNA (mtDNA) mutations, increased production of mitochondrial reactive oxygen species (ROS) and the consequent oxidative damage to nucleic acids, proteins and lipids. Mitophagy, a mitochondrial quality control mechanism enabling the degradation of damaged and superfluous mitochondria, prevents such detrimental effects and reinstates cellular homeostasis in response to stress. To date, there is increasing evidence that mitophagy is significantly impaired in several human pathologies including aging and age-related diseases such as neurodegenerative disorders, cardiovascular pathologies and cancer. Therapeutic interventions aiming at the induction of mitophagy may have the potency to ameliorate these dysfunctions. In this review, we summarize recent findings on mechanisms controlling mitophagy and its role in aging and the development of human pathologies.https://www.frontiersin.org/article/10.3389/fcell.2020.00200/fullmitophagyagingmitochondriacaloric restrictionROS |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Guo Chen Guido Kroemer Guido Kroemer Guido Kroemer Guido Kroemer Guido Kroemer Guido Kroemer Guido Kroemer Guido Kroemer Guido Kroemer Guido Kroemer Oliver Kepp Oliver Kepp Oliver Kepp Oliver Kepp Oliver Kepp Oliver Kepp Oliver Kepp |
spellingShingle |
Guo Chen Guido Kroemer Guido Kroemer Guido Kroemer Guido Kroemer Guido Kroemer Guido Kroemer Guido Kroemer Guido Kroemer Guido Kroemer Guido Kroemer Oliver Kepp Oliver Kepp Oliver Kepp Oliver Kepp Oliver Kepp Oliver Kepp Oliver Kepp Mitophagy: An Emerging Role in Aging and Age-Associated Diseases Frontiers in Cell and Developmental Biology mitophagy aging mitochondria caloric restriction ROS |
author_facet |
Guo Chen Guido Kroemer Guido Kroemer Guido Kroemer Guido Kroemer Guido Kroemer Guido Kroemer Guido Kroemer Guido Kroemer Guido Kroemer Guido Kroemer Oliver Kepp Oliver Kepp Oliver Kepp Oliver Kepp Oliver Kepp Oliver Kepp Oliver Kepp |
author_sort |
Guo Chen |
title |
Mitophagy: An Emerging Role in Aging and Age-Associated Diseases |
title_short |
Mitophagy: An Emerging Role in Aging and Age-Associated Diseases |
title_full |
Mitophagy: An Emerging Role in Aging and Age-Associated Diseases |
title_fullStr |
Mitophagy: An Emerging Role in Aging and Age-Associated Diseases |
title_full_unstemmed |
Mitophagy: An Emerging Role in Aging and Age-Associated Diseases |
title_sort |
mitophagy: an emerging role in aging and age-associated diseases |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Cell and Developmental Biology |
issn |
2296-634X |
publishDate |
2020-03-01 |
description |
Mitochondrial dysfunction constitutes one of the hallmarks of aging and is characterized by irregular mitochondrial morphology, insufficient ATP production, accumulation of mitochondrial DNA (mtDNA) mutations, increased production of mitochondrial reactive oxygen species (ROS) and the consequent oxidative damage to nucleic acids, proteins and lipids. Mitophagy, a mitochondrial quality control mechanism enabling the degradation of damaged and superfluous mitochondria, prevents such detrimental effects and reinstates cellular homeostasis in response to stress. To date, there is increasing evidence that mitophagy is significantly impaired in several human pathologies including aging and age-related diseases such as neurodegenerative disorders, cardiovascular pathologies and cancer. Therapeutic interventions aiming at the induction of mitophagy may have the potency to ameliorate these dysfunctions. In this review, we summarize recent findings on mechanisms controlling mitophagy and its role in aging and the development of human pathologies. |
topic |
mitophagy aging mitochondria caloric restriction ROS |
url |
https://www.frontiersin.org/article/10.3389/fcell.2020.00200/full |
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