Selection acts on DNA secondary structures to decrease transcriptional mutagenesis.
Single-stranded DNA is more subject to mutation than double stranded. During transcription, DNA is transiently single stranded and therefore subject to higher mutagenesis. However, if local intra-strand secondary structures are formed, some bases will be paired and therefore less sensitive to mutati...
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2006-11-01
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doaj-cf7ec6dac86e45f3aa0f23a271c7d29b2020-11-24T21:41:38ZengPublic Library of Science (PLoS)PLoS Genetics1553-73901553-74042006-11-01211e17610.1371/journal.pgen.0020176Selection acts on DNA secondary structures to decrease transcriptional mutagenesis.Claire HoedeErick DenamurOlivier TenaillonSingle-stranded DNA is more subject to mutation than double stranded. During transcription, DNA is transiently single stranded and therefore subject to higher mutagenesis. However, if local intra-strand secondary structures are formed, some bases will be paired and therefore less sensitive to mutation than unpaired bases. Using complete genome sequences of Escherichia coli, we show that local intra-strand secondary structures can, as a consequence, be used to define an index of transcription-driven mutability. At gene level, we show that natural selection has favoured a reduced transcription-driven mutagenesis via the higher than expected frequency of occurrence of intra-strand secondary structures. Such selection is stronger in highly expressed genes and suggests a sequence-dependent way to control mutation rates and a novel form of selection affecting the evolution of synonymous mutations.http://europepmc.org/articles/PMC1630709?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Claire Hoede Erick Denamur Olivier Tenaillon |
spellingShingle |
Claire Hoede Erick Denamur Olivier Tenaillon Selection acts on DNA secondary structures to decrease transcriptional mutagenesis. PLoS Genetics |
author_facet |
Claire Hoede Erick Denamur Olivier Tenaillon |
author_sort |
Claire Hoede |
title |
Selection acts on DNA secondary structures to decrease transcriptional mutagenesis. |
title_short |
Selection acts on DNA secondary structures to decrease transcriptional mutagenesis. |
title_full |
Selection acts on DNA secondary structures to decrease transcriptional mutagenesis. |
title_fullStr |
Selection acts on DNA secondary structures to decrease transcriptional mutagenesis. |
title_full_unstemmed |
Selection acts on DNA secondary structures to decrease transcriptional mutagenesis. |
title_sort |
selection acts on dna secondary structures to decrease transcriptional mutagenesis. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS Genetics |
issn |
1553-7390 1553-7404 |
publishDate |
2006-11-01 |
description |
Single-stranded DNA is more subject to mutation than double stranded. During transcription, DNA is transiently single stranded and therefore subject to higher mutagenesis. However, if local intra-strand secondary structures are formed, some bases will be paired and therefore less sensitive to mutation than unpaired bases. Using complete genome sequences of Escherichia coli, we show that local intra-strand secondary structures can, as a consequence, be used to define an index of transcription-driven mutability. At gene level, we show that natural selection has favoured a reduced transcription-driven mutagenesis via the higher than expected frequency of occurrence of intra-strand secondary structures. Such selection is stronger in highly expressed genes and suggests a sequence-dependent way to control mutation rates and a novel form of selection affecting the evolution of synonymous mutations. |
url |
http://europepmc.org/articles/PMC1630709?pdf=render |
work_keys_str_mv |
AT clairehoede selectionactsondnasecondarystructurestodecreasetranscriptionalmutagenesis AT erickdenamur selectionactsondnasecondarystructurestodecreasetranscriptionalmutagenesis AT oliviertenaillon selectionactsondnasecondarystructurestodecreasetranscriptionalmutagenesis |
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1725920802206908416 |