ISOLATION AND PRESENCE OF ANTIMALARIAL ACTIVITIES OF MARINE SPONGE <i>Xestospongia</i> sp.
Plasmodium falciparum, the agent of malignant malaria, is one of mankind's most severe scourges, mainly in the tropic world. Efforts to develop preventive vaccines or remedial drugs are handicapped by the parasite's rapid evolution of drug resistance. Here, we presented an advance work on...
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doaj-cf885fef3faf4f18af3fc70296fb61a02020-11-25T00:46:13ZengUniversitas Gadjah MadaIndonesian Journal of Chemistry1411-94202460-15782013-12-0113319920410.22146/ijc.2127614374ISOLATION AND PRESENCE OF ANTIMALARIAL ACTIVITIES OF MARINE SPONGE <i>Xestospongia</i> sp.Murtihapsari Murtihapsari0Apriani Sulu Parubak1Bertha Mangallo2Wiwied Ekasari3Puji Budi Asih4Ayu Indah Lestari5Department of Chemistry, Faculty of Mathematics and Natural Sciences, Papua State University, Jl. Gunung Salju Kampus Amban Manokwari, West Papua 98314Department of Chemistry, Faculty of Mathematics and Natural Sciences, Papua State University, Jl. Gunung Salju Kampus Amban Manokwari, West Papua 98314Department of Chemistry, Faculty of Mathematics and Natural Sciences, Papua State University, Jl. Gunung Salju Kampus Amban Manokwari, West Papua 98314Faculty of Pharmacy, Airlangga University, Kampus B Unair, Jl. Dharmawangsa Dalam Surabaya East Java 60286Eijkman Institute for Molecular Biology, Jl. Diponegoro 69, JakartaDepartment of Chemistry, Faculty of Mathematics and Natural Sciences, Papua State University, Jl. Gunung Salju Kampus Amban Manokwari, West Papua 98314Plasmodium falciparum, the agent of malignant malaria, is one of mankind's most severe scourges, mainly in the tropic world. Efforts to develop preventive vaccines or remedial drugs are handicapped by the parasite's rapid evolution of drug resistance. Here, we presented an advance work on examination of antimalarial component from marine life of Xestospongia sp., the study is based on hexane extraction method. The premier result, we obtained five fractions. Among these five fractions, the fourth has the most potent inhibitory against the growth of P. falciparum 3D7 with an IC50: 7.13 µg/mL. A compiled spectrum analysis, FTIR, 1H-NMR and GC-MS, revealed that the fourth fraction consisted abundantly of two secondary metabolites such as flavonoids and triterpenoids. Finally, our results suggest a plausible structure rooted to the base of ibuprofen.https://jurnal.ugm.ac.id/ijc/article/view/21276spongexestospongiapapuaantimalarial |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Murtihapsari Murtihapsari Apriani Sulu Parubak Bertha Mangallo Wiwied Ekasari Puji Budi Asih Ayu Indah Lestari |
spellingShingle |
Murtihapsari Murtihapsari Apriani Sulu Parubak Bertha Mangallo Wiwied Ekasari Puji Budi Asih Ayu Indah Lestari ISOLATION AND PRESENCE OF ANTIMALARIAL ACTIVITIES OF MARINE SPONGE <i>Xestospongia</i> sp. Indonesian Journal of Chemistry sponge xestospongia papua antimalarial |
author_facet |
Murtihapsari Murtihapsari Apriani Sulu Parubak Bertha Mangallo Wiwied Ekasari Puji Budi Asih Ayu Indah Lestari |
author_sort |
Murtihapsari Murtihapsari |
title |
ISOLATION AND PRESENCE OF ANTIMALARIAL ACTIVITIES OF MARINE SPONGE <i>Xestospongia</i> sp. |
title_short |
ISOLATION AND PRESENCE OF ANTIMALARIAL ACTIVITIES OF MARINE SPONGE <i>Xestospongia</i> sp. |
title_full |
ISOLATION AND PRESENCE OF ANTIMALARIAL ACTIVITIES OF MARINE SPONGE <i>Xestospongia</i> sp. |
title_fullStr |
ISOLATION AND PRESENCE OF ANTIMALARIAL ACTIVITIES OF MARINE SPONGE <i>Xestospongia</i> sp. |
title_full_unstemmed |
ISOLATION AND PRESENCE OF ANTIMALARIAL ACTIVITIES OF MARINE SPONGE <i>Xestospongia</i> sp. |
title_sort |
isolation and presence of antimalarial activities of marine sponge <i>xestospongia</i> sp. |
publisher |
Universitas Gadjah Mada |
series |
Indonesian Journal of Chemistry |
issn |
1411-9420 2460-1578 |
publishDate |
2013-12-01 |
description |
Plasmodium falciparum, the agent of malignant malaria, is one of mankind's most severe scourges, mainly in the tropic world. Efforts to develop preventive vaccines or remedial drugs are handicapped by the parasite's rapid evolution of drug resistance. Here, we presented an advance work on examination of antimalarial component from marine life of Xestospongia sp., the study is based on hexane extraction method. The premier result, we obtained five fractions. Among these five fractions, the fourth has the most potent inhibitory against the growth of P. falciparum 3D7 with an IC50: 7.13 µg/mL. A compiled spectrum analysis, FTIR, 1H-NMR and GC-MS, revealed that the fourth fraction consisted abundantly of two secondary metabolites such as flavonoids and triterpenoids. Finally, our results suggest a plausible structure rooted to the base of ibuprofen. |
topic |
sponge xestospongia papua antimalarial |
url |
https://jurnal.ugm.ac.id/ijc/article/view/21276 |
work_keys_str_mv |
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