T Regulatory Cells and Priming the Suppressive Tumor Microenvironment

Treg play a central role in maintenance of self tolerance and homeostasis through suppression of self-reactive T cell populations. In addition to that role, Treg also survey cancers and suppress anti-tumor immune responses. Thus, understanding the unique attributes of Treg-tumor interactions may per...

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Main Authors:	Christina M. Paluskievicz, Xuefang Cao, Reza Abdi, Pan Zheng, Yang Liu, Jonathan S. Bromberg
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2019-10-01
Series:	Frontiers in Immunology
Subjects:	Treg immunosuppression tumor microenvironment metastasis anti-tumor immunity
Online Access:	https://www.frontiersin.org/article/10.3389/fimmu.2019.02453/full

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spelling	doaj-cf8d5dcbb6a34842b80544f76fec79692020-11-25T02:31:29ZengFrontiers Media S.A.Frontiers in Immunology1664-32242019-10-011010.3389/fimmu.2019.02453488694T Regulatory Cells and Priming the Suppressive Tumor MicroenvironmentChristina M. Paluskievicz0Xuefang Cao1Reza Abdi2Pan Zheng3Pan Zheng4Yang Liu5Yang Liu6Jonathan S. Bromberg7Jonathan S. Bromberg8Jonathan S. Bromberg9Department of Surgery, University of Maryland School of Medicine, Baltimore, MD, United StatesDepartment of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD, United StatesDivision of Renal Medicine, Transplantation Research Center, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United StatesDepartment of Surgery, University of Maryland School of Medicine, Baltimore, MD, United StatesInstitute of Human Virology, University of Maryland School of Medicine, Baltimore, MD, United StatesDepartment of Surgery, University of Maryland School of Medicine, Baltimore, MD, United StatesInstitute of Human Virology, University of Maryland School of Medicine, Baltimore, MD, United StatesDepartment of Surgery, University of Maryland School of Medicine, Baltimore, MD, United StatesDepartment of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD, United StatesCenter for Vascular and Inflammatory Diseases, University of Maryland School of Medicine, Baltimore, MD, United StatesTreg play a central role in maintenance of self tolerance and homeostasis through suppression of self-reactive T cell populations. In addition to that role, Treg also survey cancers and suppress anti-tumor immune responses. Thus, understanding the unique attributes of Treg-tumor interactions may permit control of this pathologic suppression without interfering with homeostatic self-tolerance. This review will define the unique role of Treg in cancer growth, and the ways by which Treg inhibit a robust anti-tumor immune response. There will be specific focus placed on Treg homing to the tumor microenvironment (TME), TME formation of induced Treg (iTreg), mechanisms of suppression that underpin cancer immune escape, and trophic nonimmunologic effects of Treg on tumor cells.https://www.frontiersin.org/article/10.3389/fimmu.2019.02453/fullTregimmunosuppressiontumor microenvironmentmetastasisanti-tumor immunity
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Christina M. Paluskievicz Xuefang Cao Reza Abdi Pan Zheng Pan Zheng Yang Liu Yang Liu Jonathan S. Bromberg Jonathan S. Bromberg Jonathan S. Bromberg
spellingShingle	Christina M. Paluskievicz Xuefang Cao Reza Abdi Pan Zheng Pan Zheng Yang Liu Yang Liu Jonathan S. Bromberg Jonathan S. Bromberg Jonathan S. Bromberg T Regulatory Cells and Priming the Suppressive Tumor Microenvironment Frontiers in Immunology Treg immunosuppression tumor microenvironment metastasis anti-tumor immunity
author_facet	Christina M. Paluskievicz Xuefang Cao Reza Abdi Pan Zheng Pan Zheng Yang Liu Yang Liu Jonathan S. Bromberg Jonathan S. Bromberg Jonathan S. Bromberg
author_sort	Christina M. Paluskievicz
title	T Regulatory Cells and Priming the Suppressive Tumor Microenvironment
title_short	T Regulatory Cells and Priming the Suppressive Tumor Microenvironment
title_full	T Regulatory Cells and Priming the Suppressive Tumor Microenvironment
title_fullStr	T Regulatory Cells and Priming the Suppressive Tumor Microenvironment
title_full_unstemmed	T Regulatory Cells and Priming the Suppressive Tumor Microenvironment
title_sort	t regulatory cells and priming the suppressive tumor microenvironment
publisher	Frontiers Media S.A.
series	Frontiers in Immunology
issn	1664-3224
publishDate	2019-10-01
description	Treg play a central role in maintenance of self tolerance and homeostasis through suppression of self-reactive T cell populations. In addition to that role, Treg also survey cancers and suppress anti-tumor immune responses. Thus, understanding the unique attributes of Treg-tumor interactions may permit control of this pathologic suppression without interfering with homeostatic self-tolerance. This review will define the unique role of Treg in cancer growth, and the ways by which Treg inhibit a robust anti-tumor immune response. There will be specific focus placed on Treg homing to the tumor microenvironment (TME), TME formation of induced Treg (iTreg), mechanisms of suppression that underpin cancer immune escape, and trophic nonimmunologic effects of Treg on tumor cells.
topic	Treg immunosuppression tumor microenvironment metastasis anti-tumor immunity
url	https://www.frontiersin.org/article/10.3389/fimmu.2019.02453/full
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T Regulatory Cells and Priming the Suppressive Tumor Microenvironment

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