Intra-Arterial Delivery of Idarubicin in Two Patients with Glioblastoma

Intra-Arterial Delivery of Idarubicin in Two Patients with Glioblastoma

There is no effective treatment for recurrent glioblastoma (GB) when temozolomide-based radiochemotherapy fails. In theory, intra-arterial (IA) delivery of cytotoxic agents could achieve higher drug concentrations in tumors compared to intravenous injection. Moreover, choosing a highly lipid-soluble...

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Main Authors: Mohamad Chehimi, Mathieu Boone, Cyril Chivot, Hervé Deramond, Jean-Marc Constans, Mony Chenda Ly, Bruno Chauffert
Format: Article
Language:English
Published: Karger Publishers 2016-08-01
Series:Case Reports in Oncology
Subjects:
Idarubicin
Intra-arterial chemotherapy
Glioblastoma
Online Access:http://www.karger.com/Article/FullText/448654
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spelling doaj-cf8eb0d142714787a26641bae36ddd682020-11-25T01:06:41ZengKarger PublishersCase Reports in Oncology1662-65752016-08-019249950510.1159/000448654448654Intra-Arterial Delivery of Idarubicin in Two Patients with GlioblastomaMohamad ChehimiMathieu BooneCyril ChivotHervé DeramondJean-Marc ConstansMony Chenda LyBruno ChauffertThere is no effective treatment for recurrent glioblastoma (GB) when temozolomide-based radiochemotherapy fails. In theory, intra-arterial (IA) delivery of cytotoxic agents could achieve higher drug concentrations in tumors compared to intravenous injection. Moreover, choosing a highly lipid-soluble drug could make the most of the first-pass effect. Here, we evaluated idarubicin (IDA), a lipophilic anthracycline, in an in vitro assay using four human GB cell lines and compared it with 11 other drugs previously used for the IA treatment of brain tumors. Despite impressive in vitro cytotoxicity, IA IDA did not produce a beneficial effect in 2 patients with recurrent GB.http://www.karger.com/Article/FullText/448654IdarubicinIntra-arterial chemotherapyGlioblastoma
collection DOAJ
language English
format Article
sources DOAJ
author Mohamad Chehimi
Mathieu Boone
Cyril Chivot
Hervé Deramond
Jean-Marc Constans
Mony Chenda Ly
Bruno Chauffert
spellingShingle Mohamad Chehimi
Mathieu Boone
Cyril Chivot
Hervé Deramond
Jean-Marc Constans
Mony Chenda Ly
Bruno Chauffert
Intra-Arterial Delivery of Idarubicin in Two Patients with Glioblastoma
Case Reports in Oncology
Idarubicin
Intra-arterial chemotherapy
Glioblastoma
author_facet Mohamad Chehimi
Mathieu Boone
Cyril Chivot
Hervé Deramond
Jean-Marc Constans
Mony Chenda Ly
Bruno Chauffert
author_sort Mohamad Chehimi
title Intra-Arterial Delivery of Idarubicin in Two Patients with Glioblastoma
title_short Intra-Arterial Delivery of Idarubicin in Two Patients with Glioblastoma
title_full Intra-Arterial Delivery of Idarubicin in Two Patients with Glioblastoma
title_fullStr Intra-Arterial Delivery of Idarubicin in Two Patients with Glioblastoma
title_full_unstemmed Intra-Arterial Delivery of Idarubicin in Two Patients with Glioblastoma
title_sort intra-arterial delivery of idarubicin in two patients with glioblastoma
publisher Karger Publishers
series Case Reports in Oncology
issn 1662-6575
publishDate 2016-08-01
description There is no effective treatment for recurrent glioblastoma (GB) when temozolomide-based radiochemotherapy fails. In theory, intra-arterial (IA) delivery of cytotoxic agents could achieve higher drug concentrations in tumors compared to intravenous injection. Moreover, choosing a highly lipid-soluble drug could make the most of the first-pass effect. Here, we evaluated idarubicin (IDA), a lipophilic anthracycline, in an in vitro assay using four human GB cell lines and compared it with 11 other drugs previously used for the IA treatment of brain tumors. Despite impressive in vitro cytotoxicity, IA IDA did not produce a beneficial effect in 2 patients with recurrent GB.
topic Idarubicin
Intra-arterial chemotherapy
Glioblastoma
url http://www.karger.com/Article/FullText/448654
work_keys_str_mv AT mohamadchehimi intraarterialdeliveryofidarubicinintwopatientswithglioblastoma
AT mathieuboone intraarterialdeliveryofidarubicinintwopatientswithglioblastoma
AT cyrilchivot intraarterialdeliveryofidarubicinintwopatientswithglioblastoma
AT hervederamond intraarterialdeliveryofidarubicinintwopatientswithglioblastoma
AT jeanmarcconstans intraarterialdeliveryofidarubicinintwopatientswithglioblastoma
AT monychendaly intraarterialdeliveryofidarubicinintwopatientswithglioblastoma
AT brunochauffert intraarterialdeliveryofidarubicinintwopatientswithglioblastoma
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