A live auxotrophic vaccine confers mucosal immunity and protection against lethal pneumonia caused by Pseudomonas aeruginosa.
Pseudomonas aeruginosa is one of the leading causes of nosocomial pneumonia and its associated mortality. Moreover, extensively drug-resistant high-risk clones are globally widespread, presenting a major challenge to the healthcare systems. Despite this, no vaccine is available against this high-con...
Main Authors: | Maria P Cabral, Alexandra Correia, Manuel Vilanova, Fátima Gärtner, Miriam Moscoso, Patricia García, Juan A Vallejo, Astrid Pérez, Mónica Francisco-Tomé, Víctor Fuentes-Valverde, Germán Bou |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2020-02-01
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Series: | PLoS Pathogens |
Online Access: | https://doi.org/10.1371/journal.ppat.1008311 |
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