Identifying individual risk rare variants using protein structure guided local tests (POINT).

Identifying individual risk rare variants using protein structure guided local tests (POINT).

Rare variants are of increasing interest to genetic association studies because of their etiological contributions to human complex diseases. Due to the rarity of the mutant events, rare variants are routinely analyzed on an aggregate level. While aggregation analyses improve the detection of global...

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Bibliographic Details
Main Authors: Rachel Marceau West, Wenbin Lu, Daniel M Rotroff, Melaine A Kuenemann, Sheng-Mao Chang, Michael C Wu, Michael J Wagner, John B Buse, Alison A Motsinger-Reif, Denis Fourches, Jung-Ying Tzeng
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-02-01
Series:PLoS Computational Biology
Online Access:https://doi.org/10.1371/journal.pcbi.1006722

Internet

https://doi.org/10.1371/journal.pcbi.1006722

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