Betulinic Acid in Complex with a Gamma-Cyclodextrin Derivative Decreases Proliferation and in Vivo Tumor Development of Non-Metastatic and Metastatic B164A5 Cells
Betulinic acid, a very promising anti-melanoma agent, has very low water solubility that causes low bioavailability. To overcome this inconvenience, a highly water-soluble cyclodextrin was used (octakis-[6-deoxy-6-(2-sulfanyl ethanesulfonic acid)]-γ-cyclodextrin). The complex was physico-chemically...
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doaj-cfb271e453ad4b63a232238cefc26cf52020-11-24T23:01:13ZengMDPI AGInternational Journal of Molecular Sciences1422-00672014-05-011558235825510.3390/ijms15058235ijms15058235Betulinic Acid in Complex with a Gamma-Cyclodextrin Derivative Decreases Proliferation and in Vivo Tumor Development of Non-Metastatic and Metastatic B164A5 CellsCodruta Soica0Corina Danciu1Germaine Savoiu-Balint2Florin Borcan3Rita Ambrus4Istvan Zupko5Florina Bojin6Dorina Coricovac7Sorina Ciurlea8Stefana Avram9Cristina Adriana Dehelean10Teodora Olariu11Petru Matusz12Faculty of Pharmacy, Victor Babeş University of Medicine and Pharmacy, 2 EftimieMurgu, 300041 Timisoara, RomaniaFaculty of Pharmacy, Victor Babeş University of Medicine and Pharmacy, 2 EftimieMurgu, 300041 Timisoara, RomaniaFaculty of Pharmacy, Victor Babeş University of Medicine and Pharmacy, 2 EftimieMurgu, 300041 Timisoara, RomaniaFaculty of Pharmacy, Victor Babeş University of Medicine and Pharmacy, 2 EftimieMurgu, 300041 Timisoara, RomaniaInstitute of Pharmaceutical Technology, University of Szeged, 6 Eotvos Ut., H-6720 Szeged, HungaryDepartment of Pharmacodynamics and Biopharmacy, University of Szeged, 6 Eotvos Str., H-6720 Szeged, HungaryFaculty of Medicine, Victor Babeş University of Medicine and Pharmacy, 2 EftimieMurgu, 300041 Timisoara, RomaniaFaculty of Pharmacy, Victor Babeş University of Medicine and Pharmacy, 2 EftimieMurgu, 300041 Timisoara, RomaniaFaculty of Pharmacy, Victor Babeş University of Medicine and Pharmacy, 2 EftimieMurgu, 300041 Timisoara, RomaniaFaculty of Pharmacy, Victor Babeş University of Medicine and Pharmacy, 2 EftimieMurgu, 300041 Timisoara, RomaniaFaculty of Pharmacy, Victor Babeş University of Medicine and Pharmacy, 2 EftimieMurgu, 300041 Timisoara, RomaniaFaculty of Medicine, Vasile Goldis University, 310045 Arad, RomaniaFaculty of Medicine, Victor Babeş University of Medicine and Pharmacy, 2 EftimieMurgu, 300041 Timisoara, RomaniaBetulinic acid, a very promising anti-melanoma agent, has very low water solubility that causes low bioavailability. To overcome this inconvenience, a highly water-soluble cyclodextrin was used (octakis-[6-deoxy-6-(2-sulfanyl ethanesulfonic acid)]-γ-cyclodextrin). The complex was physico-chemically analyzed using differential scanning calorimetry (DSC), X-ray and scanning electron microscopy (SEM) methods and then in vitro tested for its antiproliferative activity by the MTT assay and by cell cycle analysis. Finally, the complex was tested in vivo using an animal model of murine melanoma developed in C57BL/6J mice, where it caused a reduction in tumor volume and weight. The study revealed the beneficial influence of betulinic acid inclusion into the cyclodextrin in terms of antiproliferative activity and in vivo tumor development.http://www.mdpi.com/1422-0067/15/5/8235betulinic acidDSCX-ray diffractionSEMMTT testC57BL/6J mice |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Codruta Soica Corina Danciu Germaine Savoiu-Balint Florin Borcan Rita Ambrus Istvan Zupko Florina Bojin Dorina Coricovac Sorina Ciurlea Stefana Avram Cristina Adriana Dehelean Teodora Olariu Petru Matusz |
spellingShingle |
Codruta Soica Corina Danciu Germaine Savoiu-Balint Florin Borcan Rita Ambrus Istvan Zupko Florina Bojin Dorina Coricovac Sorina Ciurlea Stefana Avram Cristina Adriana Dehelean Teodora Olariu Petru Matusz Betulinic Acid in Complex with a Gamma-Cyclodextrin Derivative Decreases Proliferation and in Vivo Tumor Development of Non-Metastatic and Metastatic B164A5 Cells International Journal of Molecular Sciences betulinic acid DSC X-ray diffraction SEM MTT test C57BL/6J mice |
author_facet |
Codruta Soica Corina Danciu Germaine Savoiu-Balint Florin Borcan Rita Ambrus Istvan Zupko Florina Bojin Dorina Coricovac Sorina Ciurlea Stefana Avram Cristina Adriana Dehelean Teodora Olariu Petru Matusz |
author_sort |
Codruta Soica |
title |
Betulinic Acid in Complex with a Gamma-Cyclodextrin Derivative Decreases Proliferation and in Vivo Tumor Development of Non-Metastatic and Metastatic B164A5 Cells |
title_short |
Betulinic Acid in Complex with a Gamma-Cyclodextrin Derivative Decreases Proliferation and in Vivo Tumor Development of Non-Metastatic and Metastatic B164A5 Cells |
title_full |
Betulinic Acid in Complex with a Gamma-Cyclodextrin Derivative Decreases Proliferation and in Vivo Tumor Development of Non-Metastatic and Metastatic B164A5 Cells |
title_fullStr |
Betulinic Acid in Complex with a Gamma-Cyclodextrin Derivative Decreases Proliferation and in Vivo Tumor Development of Non-Metastatic and Metastatic B164A5 Cells |
title_full_unstemmed |
Betulinic Acid in Complex with a Gamma-Cyclodextrin Derivative Decreases Proliferation and in Vivo Tumor Development of Non-Metastatic and Metastatic B164A5 Cells |
title_sort |
betulinic acid in complex with a gamma-cyclodextrin derivative decreases proliferation and in vivo tumor development of non-metastatic and metastatic b164a5 cells |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1422-0067 |
publishDate |
2014-05-01 |
description |
Betulinic acid, a very promising anti-melanoma agent, has very low water solubility that causes low bioavailability. To overcome this inconvenience, a highly water-soluble cyclodextrin was used (octakis-[6-deoxy-6-(2-sulfanyl ethanesulfonic acid)]-γ-cyclodextrin). The complex was physico-chemically analyzed using differential scanning calorimetry (DSC), X-ray and scanning electron microscopy (SEM) methods and then in vitro tested for its antiproliferative activity by the MTT assay and by cell cycle analysis. Finally, the complex was tested in vivo using an animal model of murine melanoma developed in C57BL/6J mice, where it caused a reduction in tumor volume and weight. The study revealed the beneficial influence of betulinic acid inclusion into the cyclodextrin in terms of antiproliferative activity and in vivo tumor development. |
topic |
betulinic acid DSC X-ray diffraction SEM MTT test C57BL/6J mice |
url |
http://www.mdpi.com/1422-0067/15/5/8235 |
work_keys_str_mv |
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