Betulinic Acid in Complex with a Gamma-Cyclodextrin Derivative Decreases Proliferation and in Vivo Tumor Development of Non-Metastatic and Metastatic B164A5 Cells

Betulinic Acid in Complex with a Gamma-Cyclodextrin Derivative Decreases Proliferation and in Vivo Tumor Development of Non-Metastatic and Metastatic B164A5 Cells

Betulinic acid, a very promising anti-melanoma agent, has very low water solubility that causes low bioavailability. To overcome this inconvenience, a highly water-soluble cyclodextrin was used (octakis-[6-deoxy-6-(2-sulfanyl ethanesulfonic acid)]-γ-cyclodextrin). The complex was physico-chemically...

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Bibliographic Details
Main Authors: Codruta Soica, Corina Danciu, Germaine Savoiu-Balint, Florin Borcan, Rita Ambrus, Istvan Zupko, Florina Bojin, Dorina Coricovac, Sorina Ciurlea, Stefana Avram, Cristina Adriana Dehelean, Teodora Olariu, Petru Matusz
Format: Article
Language:English
Published: MDPI AG 2014-05-01
Series:International Journal of Molecular Sciences
Subjects:
betulinic acid
DSC
X-ray diffraction
SEM
MTT test
C57BL/6J mice
Online Access:http://www.mdpi.com/1422-0067/15/5/8235

Internet

http://www.mdpi.com/1422-0067/15/5/8235

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