Layer 2/3 Pyramidal Neurons Control the Gain of Cortical Output
Summary: Initial anatomical and physiological studies suggested that sensory information relayed from the periphery by the thalamus is serially processed in primary sensory cortical areas. It is thought to propagate from layer 4 (L4) up to L2/3 and down to L5, which constitutes the main output of th...
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doaj-cfb3594232204777ace66b4dacbc341c2020-11-24T21:53:26ZengElsevierCell Reports2211-12472018-09-01241127992807.e4Layer 2/3 Pyramidal Neurons Control the Gain of Cortical OutputMichael Quiquempoix0Sophie L. Fayad1Katia Boutourlinsky2Nathalie Leresche3Régis C. Lambert4Thomas Bessaih5Sorbonne Université, CNRS, INSERM, Neurosciences Paris Seine – Institut de Biologie Paris Seine (NPS-IBPS), 75005 Paris, FranceSorbonne Université, CNRS, INSERM, Neurosciences Paris Seine – Institut de Biologie Paris Seine (NPS-IBPS), 75005 Paris, FranceSorbonne Université, CNRS, INSERM, Neurosciences Paris Seine – Institut de Biologie Paris Seine (NPS-IBPS), 75005 Paris, FranceSorbonne Université, CNRS, INSERM, Neurosciences Paris Seine – Institut de Biologie Paris Seine (NPS-IBPS), 75005 Paris, FranceSorbonne Université, CNRS, INSERM, Neurosciences Paris Seine – Institut de Biologie Paris Seine (NPS-IBPS), 75005 Paris, FranceSorbonne Université, CNRS, INSERM, Neurosciences Paris Seine – Institut de Biologie Paris Seine (NPS-IBPS), 75005 Paris, France; Corresponding authorSummary: Initial anatomical and physiological studies suggested that sensory information relayed from the periphery by the thalamus is serially processed in primary sensory cortical areas. It is thought to propagate from layer 4 (L4) up to L2/3 and down to L5, which constitutes the main output of the cortex. However, more recent experiments point toward the existence of a direct processing of thalamic input by L5 neurons. Therefore, the role of L2/3 neurons in the sensory processing operated by L5 neurons is now highly debated. Using cell type-specific and reversible optogenetic manipulations in the somatosensory cortex of both anesthetized and awake mice, we demonstrate that L2/3 pyramidal neurons play a major role in amplifying sensory-evoked responses in L5 neurons. The amplification effect scales with the velocity of the sensory stimulus, indicating that L2/3 pyramidal neurons implement gain control in deep-layer neurons. : Quiquempoix et al. investigated the role of the canonical cortical layer 2/3 (L2/3)-to-L5 pathway in sensory processing by deep-layer neurons of the mouse somatosensory cortex. They show that the recruitment of this pathway plays a major role in amplifying sensory-evoked responses in L5 neurons. Keywords: sensory processing, cortical connectivity, gain control, barrel cortex, somatosensory, whiskershttp://www.sciencedirect.com/science/article/pii/S2211124718313093 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Michael Quiquempoix Sophie L. Fayad Katia Boutourlinsky Nathalie Leresche Régis C. Lambert Thomas Bessaih |
spellingShingle |
Michael Quiquempoix Sophie L. Fayad Katia Boutourlinsky Nathalie Leresche Régis C. Lambert Thomas Bessaih Layer 2/3 Pyramidal Neurons Control the Gain of Cortical Output Cell Reports |
author_facet |
Michael Quiquempoix Sophie L. Fayad Katia Boutourlinsky Nathalie Leresche Régis C. Lambert Thomas Bessaih |
author_sort |
Michael Quiquempoix |
title |
Layer 2/3 Pyramidal Neurons Control the Gain of Cortical Output |
title_short |
Layer 2/3 Pyramidal Neurons Control the Gain of Cortical Output |
title_full |
Layer 2/3 Pyramidal Neurons Control the Gain of Cortical Output |
title_fullStr |
Layer 2/3 Pyramidal Neurons Control the Gain of Cortical Output |
title_full_unstemmed |
Layer 2/3 Pyramidal Neurons Control the Gain of Cortical Output |
title_sort |
layer 2/3 pyramidal neurons control the gain of cortical output |
publisher |
Elsevier |
series |
Cell Reports |
issn |
2211-1247 |
publishDate |
2018-09-01 |
description |
Summary: Initial anatomical and physiological studies suggested that sensory information relayed from the periphery by the thalamus is serially processed in primary sensory cortical areas. It is thought to propagate from layer 4 (L4) up to L2/3 and down to L5, which constitutes the main output of the cortex. However, more recent experiments point toward the existence of a direct processing of thalamic input by L5 neurons. Therefore, the role of L2/3 neurons in the sensory processing operated by L5 neurons is now highly debated. Using cell type-specific and reversible optogenetic manipulations in the somatosensory cortex of both anesthetized and awake mice, we demonstrate that L2/3 pyramidal neurons play a major role in amplifying sensory-evoked responses in L5 neurons. The amplification effect scales with the velocity of the sensory stimulus, indicating that L2/3 pyramidal neurons implement gain control in deep-layer neurons. : Quiquempoix et al. investigated the role of the canonical cortical layer 2/3 (L2/3)-to-L5 pathway in sensory processing by deep-layer neurons of the mouse somatosensory cortex. They show that the recruitment of this pathway plays a major role in amplifying sensory-evoked responses in L5 neurons. Keywords: sensory processing, cortical connectivity, gain control, barrel cortex, somatosensory, whiskers |
url |
http://www.sciencedirect.com/science/article/pii/S2211124718313093 |
work_keys_str_mv |
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