Can Low SHBG Serum Concentration Be A Good Early Marker Of Male Hypogonadism In Metabolic Syndrome?

• Main Authors: Jarecki P, Herman WA, Pawliczak E, Lacka K
• Format: Article
• Language: English
• Published: Dove Medical Press 2019-10-01
• Series: Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy
• Subjects: MS; DHEA; Testosterone; CRP; cholesterol; androgens
• Online Access: https://www.dovepress.com/can-low-shbg-serum-concentration-be-a-good-early-marker-of-male-hypogo-peer-reviewed-article-DMSO

Piotr Jarecki,1 Waldemar A Herman,2 Elżbieta Pawliczak,3 Katarzyna Lacka4 1Student Scientific Club of Endocrinology, Poznan University of Medical Sciences, Poznań, Wielkopolskie, Poland; 2Outpatients Clinic of Endocrine Diseases, Wschowa, Lubuskie, Poland; 3Department of Nephrology, Transplantology and Internal Medicine, Poznan University of Medical Sciences, Poznań, Wielkopolskie, Poland; 4Department of Endocrinology, Metabolism and Internal Medicine, Poznań University of Medical Sciences, Poznań, Wielkopolskie, PolandCorrespondence: Katarzyna LackaDepartment of Endocrinology, Metabolism and Internal Medicine, Poznan University of Medical Sciences, Poznań, Przybyszewskiego 49 60-834, PolandTel [phone]Email [e-mail]: In men suffering from metabolic syndrome, accompanying insulin resistance may result in a lowering of sex hormone–binding globulin (SHBG) plasma levels and cause changes in their androgenic status.Aim: The objective of the research was to assess selected androgens and SHBG plasma levels in males meeting diagnostic criteria for MS compared to healthy males.Patients and methods: The group consisted of 65 men aged between 40 and 70 years old fitting IDF metabolic syndrome criteria and 84 controls. Dehydroepiandrosterone (DHEA) and its sulphate (DHEA–S), total and free testosterone and SHBG serum levels were evaluated. Calculated free and bioavailable testosterone were estimated using an algorithm proposed by the International Society for the Study of the Aging Male.Results: Men diagnosed with MS showed a statistically significant decrease in plasma levels of DHEA in comparison to healthy ones: 11.579 (8.39–15.56) vs 14.014 (9.611–17.125) ng/mL; p = 0.0350, SHBG: 47.46 (35.78–62.83) vs 71.965 (54.45–91.56) nM/L; p<0.0001 and total testosterone: 5.2 (3.8–6.5) vs 6.3 (5.4–8.25) ng/mL; p = 0.0001 (values presented as a median with Q1–Q3).Conclusion: The results suggest that SHBG is a good early marker for metabolic dysregulation in MS, considering its strength of association and significance is comparable to, or better than, those of MS criteria.Keywords: MS, DHEA, testosterone, CRP, cholesterol, androgens