Gradients of functional connectivity in the mouse cortex reflect neocortical evolution
Understanding cortical organization is a fundamental goal of neuroscience that requires comparisons across species and modalities. Large-scale connectivity gradients have recently been introduced as a data-driven representation of the intrinsic organization of the cortex. We studied resting-state fu...
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doaj-cfbd2484ee574df280d0593e02a89add2020-12-17T04:47:24ZengElsevierNeuroImage1095-95722021-01-01225117528Gradients of functional connectivity in the mouse cortex reflect neocortical evolutionJulia M. Huntenburg0Ling Yun Yeow1Francesca Mandino2Joanes Grandjean3Systems Neuroscience Lab, Champalimaud Research, Av. Brasília, 1400-038 Lisbon, Portugal; Corresponding author.Singapore Bioimaging Consortium, Agency for Science, Technology and Research, 11 Biopolis Way, Singapore 138667, SingaporeSingapore Bioimaging Consortium, Agency for Science, Technology and Research, 11 Biopolis Way, Singapore 138667, Singapore; Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, United KingdomSingapore Bioimaging Consortium, Agency for Science, Technology and Research, 11 Biopolis Way, Singapore 138667, Singapore; Department of Radiology and Nuclear Medicine and Donders Institute for Brain, Cognition, and Behaviour, Donders Institute, Radboud University Medical Centre, Kapittelweg 29, 6525 EN Nijmegen, the NetherlandsUnderstanding cortical organization is a fundamental goal of neuroscience that requires comparisons across species and modalities. Large-scale connectivity gradients have recently been introduced as a data-driven representation of the intrinsic organization of the cortex. We studied resting-state functional connectivity gradients in the mouse cortex and found robust spatial patterns across four data sets. The principal gradient of functional connectivity shows a striking overlap with an axis of neocortical evolution from two primordial origins. Additional gradients reflect sensory specialization and aspects of a sensory-to-transmodal hierarchy, and are associated with transcriptomic features. While some of these gradients strongly resemble observations in the human cortex, the overall pattern in the mouse cortex emphasizes the specialization of sensory areas over a global functional hierarchy.http://www.sciencedirect.com/science/article/pii/S1053811920310132Cortical gradientDual originIntrinsic functional organizationMouse cortexResting-state functional connectivity |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Julia M. Huntenburg Ling Yun Yeow Francesca Mandino Joanes Grandjean |
spellingShingle |
Julia M. Huntenburg Ling Yun Yeow Francesca Mandino Joanes Grandjean Gradients of functional connectivity in the mouse cortex reflect neocortical evolution NeuroImage Cortical gradient Dual origin Intrinsic functional organization Mouse cortex Resting-state functional connectivity |
author_facet |
Julia M. Huntenburg Ling Yun Yeow Francesca Mandino Joanes Grandjean |
author_sort |
Julia M. Huntenburg |
title |
Gradients of functional connectivity in the mouse cortex reflect neocortical evolution |
title_short |
Gradients of functional connectivity in the mouse cortex reflect neocortical evolution |
title_full |
Gradients of functional connectivity in the mouse cortex reflect neocortical evolution |
title_fullStr |
Gradients of functional connectivity in the mouse cortex reflect neocortical evolution |
title_full_unstemmed |
Gradients of functional connectivity in the mouse cortex reflect neocortical evolution |
title_sort |
gradients of functional connectivity in the mouse cortex reflect neocortical evolution |
publisher |
Elsevier |
series |
NeuroImage |
issn |
1095-9572 |
publishDate |
2021-01-01 |
description |
Understanding cortical organization is a fundamental goal of neuroscience that requires comparisons across species and modalities. Large-scale connectivity gradients have recently been introduced as a data-driven representation of the intrinsic organization of the cortex. We studied resting-state functional connectivity gradients in the mouse cortex and found robust spatial patterns across four data sets. The principal gradient of functional connectivity shows a striking overlap with an axis of neocortical evolution from two primordial origins. Additional gradients reflect sensory specialization and aspects of a sensory-to-transmodal hierarchy, and are associated with transcriptomic features. While some of these gradients strongly resemble observations in the human cortex, the overall pattern in the mouse cortex emphasizes the specialization of sensory areas over a global functional hierarchy. |
topic |
Cortical gradient Dual origin Intrinsic functional organization Mouse cortex Resting-state functional connectivity |
url |
http://www.sciencedirect.com/science/article/pii/S1053811920310132 |
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