Environmental Exposure to Pesticides and Breast Cancer in a Region of Intensive Agribusiness Activity in Brazil: A Case-Control Study
<i>Background</i>: Breast cancer is a serious public health problem and is the second most prevalent cancer type in the world. The purpose of this article is to evaluate the association between pesticide use and breast cancer in a region of intense agribusiness activity in the state of M...
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doaj-cfc3b31abfd04b1a99008cf189bc159e2020-11-25T01:37:04ZengMDPI AGInternational Journal of Environmental Research and Public Health1660-46012019-10-011620395110.3390/ijerph16203951ijerph16203951Environmental Exposure to Pesticides and Breast Cancer in a Region of Intensive Agribusiness Activity in Brazil: A Case-Control StudyAgeo M. C. Silva0Paulo H. N. Campos1Inês E. Mattos2Shakoor Hajat3Eliana M. Lacerda4Marcelo J. M. Ferreira5Post Graduated Program of Environment and Health, Cuiaba University, Cuiabá 78065900, BrazilPost Graduated Program of Environment and Health, Cuiaba University, Cuiabá 78065900, BrazilNational School of Public Health, Fundação Oswaldo Cruz, Rio de Janeiro 21041-210, BrazilLondon School of Hygiene & Tropical Medicine, London WC1H 9SH, UKLondon School of Hygiene & Tropical Medicine, London WC1H 9SH, UKPost Graduated Program of Public Health, Medicine School, Federal University of Ceará, Fortaleza 60430-140, Brazil<i>Background</i>: Breast cancer is a serious public health problem and is the second most prevalent cancer type in the world. The purpose of this article is to evaluate the association between pesticide use and breast cancer in a region of intense agribusiness activity in the state of Mato Grosso, Brazil. <i>Methods</i>: A case-control study was conducted on women living in the city of Rondonópolis, in the south of Mato Grosso state. There were 85 cases of women with confirmed breast cancer and 266 controls who were randomly selected from primary health care users. Bivariate and stratified analyses were performed. Multiple logistic regression was then performed, keeping in the final model the factors with a significance level lower than or equal to 0.05 or considered important according to apriori biological criteria. <i>Results</i>: In the final model, living near cropland with pesticides (OR: 2.37; CI: 95% 1.78−3.16) and women aged over 50 years who experienced early menarche (OR: 2.08; CI: 95% 1.06−4.12) had a higher risk of developing breast cancer compared to control subjects. <i>Conclusion</i>: This study highlights the importance of exposure to pesticides as an environmental risk factor for the development of breast cancer among women.https://www.mdpi.com/1660-4601/16/20/3951breast cancerenvironmental exposurepesticideshealth surveillanceenvironmental health |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ageo M. C. Silva Paulo H. N. Campos Inês E. Mattos Shakoor Hajat Eliana M. Lacerda Marcelo J. M. Ferreira |
spellingShingle |
Ageo M. C. Silva Paulo H. N. Campos Inês E. Mattos Shakoor Hajat Eliana M. Lacerda Marcelo J. M. Ferreira Environmental Exposure to Pesticides and Breast Cancer in a Region of Intensive Agribusiness Activity in Brazil: A Case-Control Study International Journal of Environmental Research and Public Health breast cancer environmental exposure pesticides health surveillance environmental health |
author_facet |
Ageo M. C. Silva Paulo H. N. Campos Inês E. Mattos Shakoor Hajat Eliana M. Lacerda Marcelo J. M. Ferreira |
author_sort |
Ageo M. C. Silva |
title |
Environmental Exposure to Pesticides and Breast Cancer in a Region of Intensive Agribusiness Activity in Brazil: A Case-Control Study |
title_short |
Environmental Exposure to Pesticides and Breast Cancer in a Region of Intensive Agribusiness Activity in Brazil: A Case-Control Study |
title_full |
Environmental Exposure to Pesticides and Breast Cancer in a Region of Intensive Agribusiness Activity in Brazil: A Case-Control Study |
title_fullStr |
Environmental Exposure to Pesticides and Breast Cancer in a Region of Intensive Agribusiness Activity in Brazil: A Case-Control Study |
title_full_unstemmed |
Environmental Exposure to Pesticides and Breast Cancer in a Region of Intensive Agribusiness Activity in Brazil: A Case-Control Study |
title_sort |
environmental exposure to pesticides and breast cancer in a region of intensive agribusiness activity in brazil: a case-control study |
publisher |
MDPI AG |
series |
International Journal of Environmental Research and Public Health |
issn |
1660-4601 |
publishDate |
2019-10-01 |
description |
<i>Background</i>: Breast cancer is a serious public health problem and is the second most prevalent cancer type in the world. The purpose of this article is to evaluate the association between pesticide use and breast cancer in a region of intense agribusiness activity in the state of Mato Grosso, Brazil. <i>Methods</i>: A case-control study was conducted on women living in the city of Rondonópolis, in the south of Mato Grosso state. There were 85 cases of women with confirmed breast cancer and 266 controls who were randomly selected from primary health care users. Bivariate and stratified analyses were performed. Multiple logistic regression was then performed, keeping in the final model the factors with a significance level lower than or equal to 0.05 or considered important according to apriori biological criteria. <i>Results</i>: In the final model, living near cropland with pesticides (OR: 2.37; CI: 95% 1.78−3.16) and women aged over 50 years who experienced early menarche (OR: 2.08; CI: 95% 1.06−4.12) had a higher risk of developing breast cancer compared to control subjects. <i>Conclusion</i>: This study highlights the importance of exposure to pesticides as an environmental risk factor for the development of breast cancer among women. |
topic |
breast cancer environmental exposure pesticides health surveillance environmental health |
url |
https://www.mdpi.com/1660-4601/16/20/3951 |
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