Effect of an Antibacterial Polysaccharide Produced by <i>Chaetomium globosum</i> CGMCC 6882 on the Gut Microbiota of Mice
Previously, a polysaccharide produced by <i>Chaetomium</i><i>globosum</i> CGMCC 6882 was found to have antibacterial activity, but its toxic effects on body health and gut microbiota were concealed. Recent results showed that this polysaccharide was safe to Caco-2 cells and m...
Main Authors: | , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2021-05-01
|
Series: | Foods |
Subjects: | |
Online Access: | https://www.mdpi.com/2304-8158/10/5/1084 |
id |
doaj-cfc7eae01bf14483857542988b5cbf49 |
---|---|
record_format |
Article |
spelling |
doaj-cfc7eae01bf14483857542988b5cbf492021-05-31T23:58:23ZengMDPI AGFoods2304-81582021-05-01101084108410.3390/foods10051084Effect of an Antibacterial Polysaccharide Produced by <i>Chaetomium globosum</i> CGMCC 6882 on the Gut Microbiota of MiceXincheng Sun0Zichao Wang1Xuyang Hu2Chengxin Zhao3Xiaogen Zhang4Huiru Zhang5Henan Key Laboratory of Cold Chain Food Quality and Safety Control, Zhengzhou University of Light Industry, Zhengzhou 450001, ChinaCollege of Biological Engineering, Henan University of Technology, Zhengzhou 450001, ChinaHenan Key Laboratory of Cold Chain Food Quality and Safety Control, Zhengzhou University of Light Industry, Zhengzhou 450001, ChinaHenan Key Laboratory of Cold Chain Food Quality and Safety Control, Zhengzhou University of Light Industry, Zhengzhou 450001, ChinaHenan Key Laboratory of Cold Chain Food Quality and Safety Control, Zhengzhou University of Light Industry, Zhengzhou 450001, ChinaCollege of Biological Engineering, Henan University of Technology, Zhengzhou 450001, ChinaPreviously, a polysaccharide produced by <i>Chaetomium</i><i>globosum</i> CGMCC 6882 was found to have antibacterial activity, but its toxic effects on body health and gut microbiota were concealed. Recent results showed that this polysaccharide was safe to Caco-2 cells and mice, while it reduced the body weight gain of mice from 10.5 ± 1.21 g to 8.4 ± 1.17 g after 28 days administration. Acetate, propionate, butyrate and total short-chain fatty acids concentrations increased from 23.85 ± 1.37 μmol/g, 10.23 ± 0.78 μmol/g, 7.15 ± 0.35 μmol/g and 41.23 ± 0.86 μmol/g to 42.77 ± 1.29 μmol/g, 20.03 ± 1.44 μmol/g, 12.06 ± 0.51 μmol/g and 74.86 ± 2.07 μmol/g, respectively. Furthermore, this polysaccharide enriched the abundance of gut microbiota and the <i>Firmicutes</i>/<i>Bacteroidetes</i> ratio was increased from 0.5172 to 0.7238. Overall, this study provides good guidance for the promising application of polysaccharides as preservatives in foods and in other fields in the future.https://www.mdpi.com/2304-8158/10/5/1084polysaccharideantibacterial activitytoxicitybody healthgut microbiota |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Xincheng Sun Zichao Wang Xuyang Hu Chengxin Zhao Xiaogen Zhang Huiru Zhang |
spellingShingle |
Xincheng Sun Zichao Wang Xuyang Hu Chengxin Zhao Xiaogen Zhang Huiru Zhang Effect of an Antibacterial Polysaccharide Produced by <i>Chaetomium globosum</i> CGMCC 6882 on the Gut Microbiota of Mice Foods polysaccharide antibacterial activity toxicity body health gut microbiota |
author_facet |
Xincheng Sun Zichao Wang Xuyang Hu Chengxin Zhao Xiaogen Zhang Huiru Zhang |
author_sort |
Xincheng Sun |
title |
Effect of an Antibacterial Polysaccharide Produced by <i>Chaetomium globosum</i> CGMCC 6882 on the Gut Microbiota of Mice |
title_short |
Effect of an Antibacterial Polysaccharide Produced by <i>Chaetomium globosum</i> CGMCC 6882 on the Gut Microbiota of Mice |
title_full |
Effect of an Antibacterial Polysaccharide Produced by <i>Chaetomium globosum</i> CGMCC 6882 on the Gut Microbiota of Mice |
title_fullStr |
Effect of an Antibacterial Polysaccharide Produced by <i>Chaetomium globosum</i> CGMCC 6882 on the Gut Microbiota of Mice |
title_full_unstemmed |
Effect of an Antibacterial Polysaccharide Produced by <i>Chaetomium globosum</i> CGMCC 6882 on the Gut Microbiota of Mice |
title_sort |
effect of an antibacterial polysaccharide produced by <i>chaetomium globosum</i> cgmcc 6882 on the gut microbiota of mice |
publisher |
MDPI AG |
series |
Foods |
issn |
2304-8158 |
publishDate |
2021-05-01 |
description |
Previously, a polysaccharide produced by <i>Chaetomium</i><i>globosum</i> CGMCC 6882 was found to have antibacterial activity, but its toxic effects on body health and gut microbiota were concealed. Recent results showed that this polysaccharide was safe to Caco-2 cells and mice, while it reduced the body weight gain of mice from 10.5 ± 1.21 g to 8.4 ± 1.17 g after 28 days administration. Acetate, propionate, butyrate and total short-chain fatty acids concentrations increased from 23.85 ± 1.37 μmol/g, 10.23 ± 0.78 μmol/g, 7.15 ± 0.35 μmol/g and 41.23 ± 0.86 μmol/g to 42.77 ± 1.29 μmol/g, 20.03 ± 1.44 μmol/g, 12.06 ± 0.51 μmol/g and 74.86 ± 2.07 μmol/g, respectively. Furthermore, this polysaccharide enriched the abundance of gut microbiota and the <i>Firmicutes</i>/<i>Bacteroidetes</i> ratio was increased from 0.5172 to 0.7238. Overall, this study provides good guidance for the promising application of polysaccharides as preservatives in foods and in other fields in the future. |
topic |
polysaccharide antibacterial activity toxicity body health gut microbiota |
url |
https://www.mdpi.com/2304-8158/10/5/1084 |
work_keys_str_mv |
AT xinchengsun effectofanantibacterialpolysaccharideproducedbyichaetomiumglobosumicgmcc6882onthegutmicrobiotaofmice AT zichaowang effectofanantibacterialpolysaccharideproducedbyichaetomiumglobosumicgmcc6882onthegutmicrobiotaofmice AT xuyanghu effectofanantibacterialpolysaccharideproducedbyichaetomiumglobosumicgmcc6882onthegutmicrobiotaofmice AT chengxinzhao effectofanantibacterialpolysaccharideproducedbyichaetomiumglobosumicgmcc6882onthegutmicrobiotaofmice AT xiaogenzhang effectofanantibacterialpolysaccharideproducedbyichaetomiumglobosumicgmcc6882onthegutmicrobiotaofmice AT huiruzhang effectofanantibacterialpolysaccharideproducedbyichaetomiumglobosumicgmcc6882onthegutmicrobiotaofmice |
_version_ |
1721416160066404352 |