A comparative study on intraocular pressure under various anesthetics in cynomolgus monkeys (Macaca fascicularis)

• Main Authors: Hong-Soo Lee, Da-Hee Kim, Sung-Hwan Kim, Min-Sung Kang, Han Na Suh
• Format: Article
• Language: English
• Published: BMC 2021-06-01
• Series: Laboratory Animal Research
• Subjects: Anesthetics; Cynomolgus monkey; Intraocular pressure; TonoVet™
• Online Access: https://doi.org/10.1186/s42826-021-00092-2

Abstract Background Nonhuman primates (NHPs) are superior model for ocular research due to its morphological and physiological similarities with humans. Thus, the effect of four different anesthetic combinations [ketamine (10 mg/kg), ketamine + xylazine (7 + 0.6 mg/kg), zoletil (4 mg/kg), and zoletil + xylazine (4 + 0.2 mg/kg)] on intraocular pressure (IOP) was determined in cynomolgus monkeys. Results The administration of ketamine + xylazine or zoletil + xylazine resulted in lower IOP compared to ketamine or zoletil alone. Moreover, the IOP in male monkeys was higher than in females. The difference between the right and left eye was not found. Conclusions Anesthetics affected the IOP, and gender differences should be considered when measuring the IOP of nonhuman primates (NHPs).