Transcription-dependent cohesin repositioning rewires chromatin loops in cellular senescence

Transcription-dependent cohesin repositioning rewires chromatin loops in cellular senescence

Senescence is a state of stable proliferative arrest. Here, the authors perform Hi-C analysis on oncogenic RAS-induced senescence in human fibroblasts and characterize the changes in the 3D genome folding associated with the senescence-specific gene expression profile, which are mediated in part thr...

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Main Authors: Ioana Olan, Aled J. Parry, Stefan Schoenfelder, Masako Narita, Yoko Ito, Adelyne S. L. Chan, Guy St.C. Slater, Dóra Bihary, Masashige Bando, Katsuhiko Shirahige, Hiroshi Kimura, Shamith A. Samarajiwa, Peter Fraser, Masashi Narita
Format: Article
Language:English
Published: Nature Publishing Group 2020-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-19878-4
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spelling doaj-cfcc6e6ce1f94a00978bd38e7e46977b2021-05-11T08:33:12ZengNature Publishing GroupNature Communications2041-17232020-11-0111111410.1038/s41467-020-19878-4Transcription-dependent cohesin repositioning rewires chromatin loops in cellular senescenceIoana Olan0Aled J. Parry1Stefan Schoenfelder2Masako Narita3Yoko Ito4Adelyne S. L. Chan5Guy St.C. Slater6Dóra Bihary7Masashige Bando8Katsuhiko Shirahige9Hiroshi Kimura10Shamith A. Samarajiwa11Peter Fraser12Masashi Narita13Cancer Research UK Cambridge Institute, University of CambridgeCancer Research UK Cambridge Institute, University of CambridgeEpigenetics Programme, The Babraham Institute, Babraham Research CampusCancer Research UK Cambridge Institute, University of CambridgeCancer Research UK Cambridge Institute, University of CambridgeCancer Research UK Cambridge Institute, University of CambridgeCancer Research UK Cambridge Institute, University of CambridgeMRC Cancer Unit, Hutchison/MRC Research Centre, University of Cambridge, Cambridge Biomedical CampusLaboratory of Genome Structure and Function, Institute of Molecular and Cellular Biosciences, The University of TokyoLaboratory of Genome Structure and Function, Institute of Molecular and Cellular Biosciences, The University of TokyoCell Biology Centre, Institute of Innovative Research, Tokyo Institute of TechnologyMRC Cancer Unit, Hutchison/MRC Research Centre, University of Cambridge, Cambridge Biomedical CampusNuclear Dynamics Programme, The Babraham Institute, Babraham Research CampusCancer Research UK Cambridge Institute, University of CambridgeSenescence is a state of stable proliferative arrest. Here, the authors perform Hi-C analysis on oncogenic RAS-induced senescence in human fibroblasts and characterize the changes in the 3D genome folding associated with the senescence-specific gene expression profile, which are mediated in part through cohesin redistribution on chromatin.https://doi.org/10.1038/s41467-020-19878-4
collection DOAJ
language English
format Article
sources DOAJ
author Ioana Olan
Aled J. Parry
Stefan Schoenfelder
Masako Narita
Yoko Ito
Adelyne S. L. Chan
Guy St.C. Slater
Dóra Bihary
Masashige Bando
Katsuhiko Shirahige
Hiroshi Kimura
Shamith A. Samarajiwa
Peter Fraser
Masashi Narita
spellingShingle Ioana Olan
Aled J. Parry
Stefan Schoenfelder
Masako Narita
Yoko Ito
Adelyne S. L. Chan
Guy St.C. Slater
Dóra Bihary
Masashige Bando
Katsuhiko Shirahige
Hiroshi Kimura
Shamith A. Samarajiwa
Peter Fraser
Masashi Narita
Transcription-dependent cohesin repositioning rewires chromatin loops in cellular senescence
Nature Communications
author_facet Ioana Olan
Aled J. Parry
Stefan Schoenfelder
Masako Narita
Yoko Ito
Adelyne S. L. Chan
Guy St.C. Slater
Dóra Bihary
Masashige Bando
Katsuhiko Shirahige
Hiroshi Kimura
Shamith A. Samarajiwa
Peter Fraser
Masashi Narita
author_sort Ioana Olan
title Transcription-dependent cohesin repositioning rewires chromatin loops in cellular senescence
title_short Transcription-dependent cohesin repositioning rewires chromatin loops in cellular senescence
title_full Transcription-dependent cohesin repositioning rewires chromatin loops in cellular senescence
title_fullStr Transcription-dependent cohesin repositioning rewires chromatin loops in cellular senescence
title_full_unstemmed Transcription-dependent cohesin repositioning rewires chromatin loops in cellular senescence
title_sort transcription-dependent cohesin repositioning rewires chromatin loops in cellular senescence
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2020-11-01
description Senescence is a state of stable proliferative arrest. Here, the authors perform Hi-C analysis on oncogenic RAS-induced senescence in human fibroblasts and characterize the changes in the 3D genome folding associated with the senescence-specific gene expression profile, which are mediated in part through cohesin redistribution on chromatin.
url https://doi.org/10.1038/s41467-020-19878-4
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