Microbial and metabolic impacts of trehalose and trehalose analogues
Trehalose is a disaccharide and fasting-mimetic that has been both canonized and vilified for its putative cardiometabolic and microbial effects. Trehalose analogues are currently under development to extend the key metabolic therapeutic actions of trehalose without adversely affecting host microbia...
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2020-09-01
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Online Access: | http://dx.doi.org/10.1080/19490976.2020.1750273 |
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doaj-cfd357ace2e3401f86e28ccf83ddbefd2021-09-20T13:17:20ZengTaylor & Francis GroupGut Microbes1949-09761949-09842020-09-011151475148210.1080/19490976.2020.17502731750273Microbial and metabolic impacts of trehalose and trehalose analoguesYiming Zhang0Brian J. DeBosch1Washington University School of MedicineWashington University School of MedicineTrehalose is a disaccharide and fasting-mimetic that has been both canonized and vilified for its putative cardiometabolic and microbial effects. Trehalose analogues are currently under development to extend the key metabolic therapeutic actions of trehalose without adversely affecting host microbial communities. In the current study, we contrast the extent to which trehalose and its degradation-resistant analogue, lactotrehalose (LT), modulate microbial communities and host transcriptomic profiles. We demonstrate that trehalose and LT each exert adaptive metabolic and microbial effects that both overlap and diverge. We postulate that these effects depend both upon compound stability and bioavailability, and on stereospecific signal transduction. In context, the data suggest that trehalose is unlikely to be harmful, and yet it harbors unique effects that are not yet fully replicated by its analogues. These compounds are thus valuable probes to better define trehalose structure-function, and to offer as therapeutic metabolic agents.http://dx.doi.org/10.1080/19490976.2020.1750273clostridioides difficiletrehalosenafldmicrobiomelactotrehalose |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yiming Zhang Brian J. DeBosch |
spellingShingle |
Yiming Zhang Brian J. DeBosch Microbial and metabolic impacts of trehalose and trehalose analogues Gut Microbes clostridioides difficile trehalose nafld microbiome lactotrehalose |
author_facet |
Yiming Zhang Brian J. DeBosch |
author_sort |
Yiming Zhang |
title |
Microbial and metabolic impacts of trehalose and trehalose analogues |
title_short |
Microbial and metabolic impacts of trehalose and trehalose analogues |
title_full |
Microbial and metabolic impacts of trehalose and trehalose analogues |
title_fullStr |
Microbial and metabolic impacts of trehalose and trehalose analogues |
title_full_unstemmed |
Microbial and metabolic impacts of trehalose and trehalose analogues |
title_sort |
microbial and metabolic impacts of trehalose and trehalose analogues |
publisher |
Taylor & Francis Group |
series |
Gut Microbes |
issn |
1949-0976 1949-0984 |
publishDate |
2020-09-01 |
description |
Trehalose is a disaccharide and fasting-mimetic that has been both canonized and vilified for its putative cardiometabolic and microbial effects. Trehalose analogues are currently under development to extend the key metabolic therapeutic actions of trehalose without adversely affecting host microbial communities. In the current study, we contrast the extent to which trehalose and its degradation-resistant analogue, lactotrehalose (LT), modulate microbial communities and host transcriptomic profiles. We demonstrate that trehalose and LT each exert adaptive metabolic and microbial effects that both overlap and diverge. We postulate that these effects depend both upon compound stability and bioavailability, and on stereospecific signal transduction. In context, the data suggest that trehalose is unlikely to be harmful, and yet it harbors unique effects that are not yet fully replicated by its analogues. These compounds are thus valuable probes to better define trehalose structure-function, and to offer as therapeutic metabolic agents. |
topic |
clostridioides difficile trehalose nafld microbiome lactotrehalose |
url |
http://dx.doi.org/10.1080/19490976.2020.1750273 |
work_keys_str_mv |
AT yimingzhang microbialandmetabolicimpactsoftrehaloseandtrehaloseanalogues AT brianjdebosch microbialandmetabolicimpactsoftrehaloseandtrehaloseanalogues |
_version_ |
1717374366852841472 |