Pneumococcal Serotypes before and after Introduction of Conjugate Vaccines, United States, 1999–2011
Serotyping data for pneumococci causing invasive and noninvasive disease in 2008–2009 and 2010–2011 from >43 US centers were compared with data from preconjugate vaccine (1999–2000) and postconjugate vaccine (2004–2005) periods. Prevalence of 7-valent pneumococcal conjugate vaccine serotypes decr...
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doaj-cfd462806fe042bdb0b81113454d50e22020-11-24T21:50:28ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592013-07-011971074108310.3201/eid1907.121830Pneumococcal Serotypes before and after Introduction of Conjugate Vaccines, United States, 1999–2011Sandra S. RichterKristopher P. HeilmannCassie L. DohrnFathollah RiahiDaniel J. DiekemaGary V. DoernSerotyping data for pneumococci causing invasive and noninvasive disease in 2008–2009 and 2010–2011 from >43 US centers were compared with data from preconjugate vaccine (1999–2000) and postconjugate vaccine (2004–2005) periods. Prevalence of 7-valent pneumococcal conjugate vaccine serotypes decreased from 64% of invasive and 50% of noninvasive isolates in 1999–2000 to 3.8% and 4.2%, respectively, in 2010–2011. Increases in serotype 19A stopped after introduction of 13-valent pneumococcal vaccine (PCV13) in 2010. Prevalences of other predominant serotypes included in or related to PCV13 (3, 6C, 7F) also remained similar for 2008–2009 and 2010–2011. The only major serotype that increased from 2008–2009 to 2010–2011 was nonvaccine serotype 35B. These data show that introduction of the 7-valent vaccine has dramatically decreased prevalence of its serotypes and that addition of serotypes in PCV13 could provide coverage of 39% of isolates that continue to cause disease. https://wwwnc.cdc.gov/eid/article/19/7/12-1830_articleStreptococcus pneumoniaebacteriaserotypevaccineconjugate vaccinespathogenesis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Sandra S. Richter Kristopher P. Heilmann Cassie L. Dohrn Fathollah Riahi Daniel J. Diekema Gary V. Doern |
spellingShingle |
Sandra S. Richter Kristopher P. Heilmann Cassie L. Dohrn Fathollah Riahi Daniel J. Diekema Gary V. Doern Pneumococcal Serotypes before and after Introduction of Conjugate Vaccines, United States, 1999–2011 Emerging Infectious Diseases Streptococcus pneumoniae bacteria serotype vaccine conjugate vaccines pathogenesis |
author_facet |
Sandra S. Richter Kristopher P. Heilmann Cassie L. Dohrn Fathollah Riahi Daniel J. Diekema Gary V. Doern |
author_sort |
Sandra S. Richter |
title |
Pneumococcal Serotypes before and after Introduction of Conjugate Vaccines, United States, 1999–2011 |
title_short |
Pneumococcal Serotypes before and after Introduction of Conjugate Vaccines, United States, 1999–2011 |
title_full |
Pneumococcal Serotypes before and after Introduction of Conjugate Vaccines, United States, 1999–2011 |
title_fullStr |
Pneumococcal Serotypes before and after Introduction of Conjugate Vaccines, United States, 1999–2011 |
title_full_unstemmed |
Pneumococcal Serotypes before and after Introduction of Conjugate Vaccines, United States, 1999–2011 |
title_sort |
pneumococcal serotypes before and after introduction of conjugate vaccines, united states, 1999–2011 |
publisher |
Centers for Disease Control and Prevention |
series |
Emerging Infectious Diseases |
issn |
1080-6040 1080-6059 |
publishDate |
2013-07-01 |
description |
Serotyping data for pneumococci causing invasive and noninvasive disease in 2008–2009 and 2010–2011 from >43 US centers were compared with data from preconjugate vaccine (1999–2000) and postconjugate vaccine (2004–2005) periods. Prevalence of 7-valent pneumococcal conjugate vaccine serotypes decreased from 64% of invasive and 50% of noninvasive isolates in 1999–2000 to 3.8% and 4.2%, respectively, in 2010–2011. Increases in serotype 19A stopped after introduction of 13-valent pneumococcal vaccine (PCV13) in 2010. Prevalences of other predominant serotypes included in or related to PCV13 (3, 6C, 7F) also remained similar for 2008–2009 and 2010–2011. The only major serotype that increased from 2008–2009 to 2010–2011 was nonvaccine serotype 35B. These data show that introduction of the 7-valent vaccine has dramatically decreased prevalence of its serotypes and that addition of serotypes in PCV13 could provide coverage of 39% of isolates that continue to cause disease. |
topic |
Streptococcus pneumoniae bacteria serotype vaccine conjugate vaccines pathogenesis |
url |
https://wwwnc.cdc.gov/eid/article/19/7/12-1830_article |
work_keys_str_mv |
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