Biological Age Predictors
The search for reliable indicators of biological age, rather than chronological age, has been ongoing for over three decades, and until recently, largely without success. Advances in the fields of molecular biology have increased the variety of potential candidate biomarkers that may be considered a...
Main Authors: | , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2017-07-01
|
Series: | EBioMedicine |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2352396417301421 |
id |
doaj-cfd5b175614f4dadaaeb14470cd719da |
---|---|
record_format |
Article |
spelling |
doaj-cfd5b175614f4dadaaeb14470cd719da2020-11-25T00:07:11ZengElsevierEBioMedicine2352-39642017-07-0121C293610.1016/j.ebiom.2017.03.046Biological Age PredictorsJuulia JylhäväNancy L. PedersenSara HäggThe search for reliable indicators of biological age, rather than chronological age, has been ongoing for over three decades, and until recently, largely without success. Advances in the fields of molecular biology have increased the variety of potential candidate biomarkers that may be considered as biological age predictors. In this review, we summarize current state-of-the-art findings considering six potential types of biological age predictors: epigenetic clocks, telomere length, transcriptomic predictors, proteomic predictors, metabolomics-based predictors, and composite biomarker predictors. Promising developments consider multiple combinations of these various types of predictors, which may shed light on the aging process and provide further understanding of what contributes to healthy aging. Thus far, the most promising, new biological age predictor is the epigenetic clock; however its true value as a biomarker of aging requires longitudinal confirmation.http://www.sciencedirect.com/science/article/pii/S2352396417301421AgingBiomarkerPredictionEpigenetic clockTelomere length |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Juulia Jylhävä Nancy L. Pedersen Sara Hägg |
spellingShingle |
Juulia Jylhävä Nancy L. Pedersen Sara Hägg Biological Age Predictors EBioMedicine Aging Biomarker Prediction Epigenetic clock Telomere length |
author_facet |
Juulia Jylhävä Nancy L. Pedersen Sara Hägg |
author_sort |
Juulia Jylhävä |
title |
Biological Age Predictors |
title_short |
Biological Age Predictors |
title_full |
Biological Age Predictors |
title_fullStr |
Biological Age Predictors |
title_full_unstemmed |
Biological Age Predictors |
title_sort |
biological age predictors |
publisher |
Elsevier |
series |
EBioMedicine |
issn |
2352-3964 |
publishDate |
2017-07-01 |
description |
The search for reliable indicators of biological age, rather than chronological age, has been ongoing for over three decades, and until recently, largely without success. Advances in the fields of molecular biology have increased the variety of potential candidate biomarkers that may be considered as biological age predictors. In this review, we summarize current state-of-the-art findings considering six potential types of biological age predictors: epigenetic clocks, telomere length, transcriptomic predictors, proteomic predictors, metabolomics-based predictors, and composite biomarker predictors. Promising developments consider multiple combinations of these various types of predictors, which may shed light on the aging process and provide further understanding of what contributes to healthy aging. Thus far, the most promising, new biological age predictor is the epigenetic clock; however its true value as a biomarker of aging requires longitudinal confirmation. |
topic |
Aging Biomarker Prediction Epigenetic clock Telomere length |
url |
http://www.sciencedirect.com/science/article/pii/S2352396417301421 |
work_keys_str_mv |
AT juuliajylhava biologicalagepredictors AT nancylpedersen biologicalagepredictors AT sarahagg biologicalagepredictors |
_version_ |
1725419590634176512 |