Brain microvasculature defects and Glut1 deficiency syndrome averted by early repletion of the glucose transporter-1 protein
Glut1-deficiency syndrome is a severe neurodevelopmental disorder characterized by low brain glucose and epileptic seizures. Tanget al. show that in model mice, low Glut1 leads to defects of the brain vasculature, and that AAV9-based gene therapy at pre- or early-symptomatic stages prevents the defe...
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Bibliographic Details
Main Authors: |
Maoxue Tang,
Guangping Gao,
Carlos B. Rueda,
Hang Yu,
David N. Thibodeaux,
Tomoyuki Awano,
Kristin M. Engelstad,
Maria-Jose Sanchez-Quintero,
Hong Yang,
Fanghua Li,
Huapeng Li,
Qin Su,
Kara E. Shetler,
Lynne Jones,
Ryan Seo,
Jonathan McConathy,
Elizabeth M. Hillman,
Jeffrey L. Noebels,
Darryl C. De Vivo,
Umrao R. Monani |
Format: | Article
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Language: | English |
Published: |
Nature Publishing Group
2017-01-01
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Series: | Nature Communications
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Online Access: | https://doi.org/10.1038/ncomms14152
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