Angiopoietin receptor Tie2 is required for vein specification and maintenance via regulating COUP-TFII

Angiopoietin receptor Tie2 is required for vein specification and maintenance via regulating COUP-TFII

Mechanisms underlying the vein development remain largely unknown. Tie2 signaling mediates endothelial cell (EC) survival and vascular maturation and its activating mutations are linked to venous malformations. Here we show that vein formation are disrupted in mouse skin and mesentery when Tie2 sign...

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Bibliographic Details
Main Authors: Man Chu, Taotao Li, Bin Shen, Xudong Cao, Haoyu Zhong, Luqing Zhang, Fei Zhou, Wenjuan Ma, Haijuan Jiang, Pancheng Xie, Zhengzheng Liu, Ningzheng Dong, Ying Xu, Yun Zhao, Guoqiang Xu, Peirong Lu, Jincai Luo, Qingyu Wu, Kari Alitalo, Gou Young Koh, Ralf H Adams, Yulong He
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-12-01
Series:eLife
Subjects:
Tie2
COUP-TFII
vein specification
Online Access:https://elifesciences.org/articles/21032

Internet

https://elifesciences.org/articles/21032

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