Dysregulation of Notch signaling related genes in oral lichen planus

• Main Authors: Nunthawan Nowwarote, Thanaphum Osathanon
• Format: Article
• Language: English
• Published: Wolters Kluwer Medknow Publications 2017-07-01
• Series: Asian Pacific Journal of Tropical Biomedicine
• Subjects: Notch signaling; Oral lichen planus; Expression analysis; Genes
• Online Access: http://www.sciencedirect.com/science/article/pii/S2221169117306718

Objective: To investigate a dysregulation of Notch signaling in oral lichen planus (OLP) using public available microarray dataset. Methods: A mRNA expression profiling dataset from Gene Expression Omnibus was downloaded. Differential gene expression between OLP and normal oral epithelium was examined using NetworkAnalyst. The dysregulated genes related to Notch signaling were identified. Results: Thirteen genes in Notch signaling pathway were significantly differential expressed between OLP and normal epithelium. OLP samples significantly increased the mRNA levels of HEYL, APH1B, CNTN1 and PSEN2. Whilst, ITCH, HES1, TLE2, DLK2, DTX2, NOTCH3, JAG2, RFNG, and SPEN were downregulated in OLP groups. Conclusions: Notch signaling was dysregulated and may participate in pathophysiologic process in OLP.