Recombinant Lassa Virus Expressing Green Fluorescent Protein as a Tool for High-Throughput Drug Screens and Neutralizing Antibody Assays

Recombinant Lassa Virus Expressing Green Fluorescent Protein as a Tool for High-Throughput Drug Screens and Neutralizing Antibody Assays

Lassa virus (LASV), a mammarenavirus, infects an estimated 100,000⁻300,000 individuals yearly in western Africa and frequently causes lethal disease. Currently, no LASV-specific antivirals or vaccines are commercially available for prevention or treatment of Lassa fever, the disease caused...

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Bibliographic Details
Main Authors: Yíngyún Caì, Masaharu Iwasaki, Brett F. Beitzel, Shuīqìng Yú, Elena N. Postnikova, Beatrice Cubitt, Lisa Evans DeWald, Sheli R. Radoshitzky, Laura Bollinger, Peter B. Jahrling, Gustavo F. Palacios, Juan C. de la Torre, Jens H. Kuhn
Format: Article
Language:English
Published: MDPI AG 2018-11-01
Series:Viruses
Subjects:
<i>Arenaviridae</i>
arenavirus
biosafety level 4
BSL-4
drug screening
Lassa fever
Lassa virus
LASV
mammarenavirus
reverse genetics
Online Access:https://www.mdpi.com/1999-4915/10/11/655

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