Periodontal Disease and Breast Cancer: A Meta-Analysis of 1,73,162 Participants
Objective: To investigate the correlation between periodontal disease and breast cancer.Materials and Methods: PubMed and China National Knowledge Infrastructure (CNKI) databases were searched up to February 8, 2018 for observational studies examining the association between periodontal disease and...
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Frontiers Media S.A.
2018-12-01
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doaj-d0015d215d8847a3b22c8a1b8e6f3ee92020-11-25T00:49:11ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2018-12-01810.3389/fonc.2018.00601422935Periodontal Disease and Breast Cancer: A Meta-Analysis of 1,73,162 ParticipantsJun Shao0Lan Wu1Lan Wu2Lan Wu3Wei-Dong Leng4Cheng Fang5Cheng Fang6You-Jia Zhu7Ying-Hui Jin8Ying-Hui Jin9Xian-Tao Zeng10Xian-Tao Zeng11Xian-Tao Zeng12Xian-Tao Zeng13Xian-Tao Zeng14Department of Stomatology, Guangzhou Hospital of Integrated Traditional and West Medicine, Guangzhou, ChinaCenter for Evidence-Based and Translational Medicine, Zhongnan Hospital of Wuhan University, Wuhan, ChinaDepartment of Evidence-Based Medicine and Clinical Epidemiology, The Second Clinical College of Wuhan University, Wuhan, ChinaDepartment of Stomatology, Zhongnan Hospital of Wuhan University, Wuhan, ChinaDepartment of Stomatology, Taihe Hospital, Hubei University of Medicine, Shiyan, ChinaCenter for Evidence-Based and Translational Medicine, Zhongnan Hospital of Wuhan University, Wuhan, ChinaDepartment of Evidence-Based Medicine and Clinical Epidemiology, The Second Clinical College of Wuhan University, Wuhan, ChinaDepartment of Stomatology, Zhongnan Hospital of Wuhan University, Wuhan, ChinaCenter for Evidence-Based and Translational Medicine, Zhongnan Hospital of Wuhan University, Wuhan, ChinaDepartment of Evidence-Based Medicine and Clinical Epidemiology, The Second Clinical College of Wuhan University, Wuhan, ChinaDepartment of Stomatology, Guangzhou Hospital of Integrated Traditional and West Medicine, Guangzhou, ChinaCenter for Evidence-Based and Translational Medicine, Zhongnan Hospital of Wuhan University, Wuhan, ChinaDepartment of Evidence-Based Medicine and Clinical Epidemiology, The Second Clinical College of Wuhan University, Wuhan, ChinaDepartment of Stomatology, Zhongnan Hospital of Wuhan University, Wuhan, ChinaDepartment of Stomatology, Taihe Hospital, Hubei University of Medicine, Shiyan, ChinaObjective: To investigate the correlation between periodontal disease and breast cancer.Materials and Methods: PubMed and China National Knowledge Infrastructure (CNKI) databases were searched up to February 8, 2018 for observational studies examining the association between periodontal disease and breast cancer. Study selection was conducted according to predesigned eligibility criteria, and two authors independently extracted data from included studies. Meta-analysis was performed using the Comprehensive Meta-Analysis v2 software and risk estimates were calculated as relative risks (RRs) with corresponding 95% confidence intervals (CIs).Results: A total of 11 study were included. Meta-analysis indicated that periodontal disease significantly increased the risk of breast cancer by 1.22-fold (RR = 1.22, 95% CI = 1.06–1.40). Amongst participants with periodontal patients and a history of periodontal therapy, the risk of developing breast cancer was not significant (RR = 1.23; 95% CI = 0.95–1.60). The association results between periodontal diseases and breast cancer were found to be robust, as evident in the leave-one-out sensitivity analysis.Conclusions: Periodontal disease may be a potential risk factor for the development of breast cancer among women, and thus effective periodontal therapy may present as a valuable preventive measure against breast cancer.https://www.frontiersin.org/article/10.3389/fonc.2018.00601/fullperiodontal diseasebreast cancerrisk factorperiodontal therapymeta-analysis |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jun Shao Lan Wu Lan Wu Lan Wu Wei-Dong Leng Cheng Fang Cheng Fang You-Jia Zhu Ying-Hui Jin Ying-Hui Jin Xian-Tao Zeng Xian-Tao Zeng Xian-Tao Zeng Xian-Tao Zeng Xian-Tao Zeng |
spellingShingle |
Jun Shao Lan Wu Lan Wu Lan Wu Wei-Dong Leng Cheng Fang Cheng Fang You-Jia Zhu Ying-Hui Jin Ying-Hui Jin Xian-Tao Zeng Xian-Tao Zeng Xian-Tao Zeng Xian-Tao Zeng Xian-Tao Zeng Periodontal Disease and Breast Cancer: A Meta-Analysis of 1,73,162 Participants Frontiers in Oncology periodontal disease breast cancer risk factor periodontal therapy meta-analysis |
author_facet |
Jun Shao Lan Wu Lan Wu Lan Wu Wei-Dong Leng Cheng Fang Cheng Fang You-Jia Zhu Ying-Hui Jin Ying-Hui Jin Xian-Tao Zeng Xian-Tao Zeng Xian-Tao Zeng Xian-Tao Zeng Xian-Tao Zeng |
author_sort |
Jun Shao |
title |
Periodontal Disease and Breast Cancer: A Meta-Analysis of 1,73,162 Participants |
title_short |
Periodontal Disease and Breast Cancer: A Meta-Analysis of 1,73,162 Participants |
title_full |
Periodontal Disease and Breast Cancer: A Meta-Analysis of 1,73,162 Participants |
title_fullStr |
Periodontal Disease and Breast Cancer: A Meta-Analysis of 1,73,162 Participants |
title_full_unstemmed |
Periodontal Disease and Breast Cancer: A Meta-Analysis of 1,73,162 Participants |
title_sort |
periodontal disease and breast cancer: a meta-analysis of 1,73,162 participants |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Oncology |
issn |
2234-943X |
publishDate |
2018-12-01 |
description |
Objective: To investigate the correlation between periodontal disease and breast cancer.Materials and Methods: PubMed and China National Knowledge Infrastructure (CNKI) databases were searched up to February 8, 2018 for observational studies examining the association between periodontal disease and breast cancer. Study selection was conducted according to predesigned eligibility criteria, and two authors independently extracted data from included studies. Meta-analysis was performed using the Comprehensive Meta-Analysis v2 software and risk estimates were calculated as relative risks (RRs) with corresponding 95% confidence intervals (CIs).Results: A total of 11 study were included. Meta-analysis indicated that periodontal disease significantly increased the risk of breast cancer by 1.22-fold (RR = 1.22, 95% CI = 1.06–1.40). Amongst participants with periodontal patients and a history of periodontal therapy, the risk of developing breast cancer was not significant (RR = 1.23; 95% CI = 0.95–1.60). The association results between periodontal diseases and breast cancer were found to be robust, as evident in the leave-one-out sensitivity analysis.Conclusions: Periodontal disease may be a potential risk factor for the development of breast cancer among women, and thus effective periodontal therapy may present as a valuable preventive measure against breast cancer. |
topic |
periodontal disease breast cancer risk factor periodontal therapy meta-analysis |
url |
https://www.frontiersin.org/article/10.3389/fonc.2018.00601/full |
work_keys_str_mv |
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