A comprehensive analysis of candidate genes in familial pancreatic cancer families reveals a high frequency of potentially pathogenic germline variants

A comprehensive analysis of candidate genes in familial pancreatic cancer families reveals a high frequency of potentially pathogenic germline variants

Background: The 5-year survival rate of patients with pancreatic ductal adenocarcinoma (PDAC) is around 5% due to the fact that the majority of patients present with advanced disease that is treatment resistant. Familial pancreatic cancer (FPC) is a rare disorder that is defined as a family with at...

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Bibliographic Details
Main Authors:	Julie Earl, Cristina Galindo-Pumariño, Jessica Encinas, Emma Barreto, Maria E. Castillo, Vanessa Pachón, Reyes Ferreiro, Mercedes Rodríguez-Garrote, Silvia González-Martínez, Teresa Ramon y Cajal, Luis Robles Diaz, Isabel Chirivella-Gonzalez, Montse Rodriguez, Eva Martínez de Castro, David García-Seisdedos, Gloria Muñoz, Juan Manuel Rosa Rosa, Mirari Marquez, Nuría Malats, Alfredo Carrato
Format:	Article
Language:	English
Published:	Elsevier 2020-03-01
Series:	EBioMedicine
Online Access:	http://www.sciencedirect.com/science/article/pii/S2352396420300505

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