Prophylactic orthosteric inhibition of leukocyte integrin CD11b/CD18 prevents long-term fibrotic kidney failure in cynomolgus monkeys

Prophylactic orthosteric inhibition of leukocyte integrin CD11b/CD18 prevents long-term fibrotic kidney failure in cynomolgus monkeys

Acute kidney injury can progress to chronic kidney disease. Here Dehnadiet al. develop a post-ischaemic chronic kidney disease model in cynomolgus monkeys and show that prophylactic inhibition of CD11b/CD18 leukocyte receptor via a monoclonal antibody inhibits progression of kidney disease and fibro...

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Main Authors: Abbas Dehnadi, A. Benedict Cosimi, Rex Neal Smith, Xiangen Li, José L. Alonso, Terry K. Means, M. Amin Arnaout
Format: Article
Language:English
Published: Nature Publishing Group 2017-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms13899
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spelling doaj-d0055b59431d4c87ad00b0f2699199252021-05-11T07:07:37ZengNature Publishing GroupNature Communications2041-17232017-01-018111110.1038/ncomms13899Prophylactic orthosteric inhibition of leukocyte integrin CD11b/CD18 prevents long-term fibrotic kidney failure in cynomolgus monkeysAbbas Dehnadi0A. Benedict Cosimi1Rex Neal Smith2Xiangen Li3José L. Alonso4Terry K. Means5M. Amin Arnaout6Division of Transplant Surgery, Department of Surgery, Massachusetts General HospitalDivision of Transplant Surgery, Department of Surgery, Massachusetts General HospitalHarvard Medical SchoolHarvard Medical SchoolHarvard Medical SchoolHarvard Medical SchoolHarvard Medical SchoolAcute kidney injury can progress to chronic kidney disease. Here Dehnadiet al. develop a post-ischaemic chronic kidney disease model in cynomolgus monkeys and show that prophylactic inhibition of CD11b/CD18 leukocyte receptor via a monoclonal antibody inhibits progression of kidney disease and fibrosis.https://doi.org/10.1038/ncomms13899
collection DOAJ
language English
format Article
sources DOAJ
author Abbas Dehnadi
A. Benedict Cosimi
Rex Neal Smith
Xiangen Li
José L. Alonso
Terry K. Means
M. Amin Arnaout
spellingShingle Abbas Dehnadi
A. Benedict Cosimi
Rex Neal Smith
Xiangen Li
José L. Alonso
Terry K. Means
M. Amin Arnaout
Prophylactic orthosteric inhibition of leukocyte integrin CD11b/CD18 prevents long-term fibrotic kidney failure in cynomolgus monkeys
Nature Communications
author_facet Abbas Dehnadi
A. Benedict Cosimi
Rex Neal Smith
Xiangen Li
José L. Alonso
Terry K. Means
M. Amin Arnaout
author_sort Abbas Dehnadi
title Prophylactic orthosteric inhibition of leukocyte integrin CD11b/CD18 prevents long-term fibrotic kidney failure in cynomolgus monkeys
title_short Prophylactic orthosteric inhibition of leukocyte integrin CD11b/CD18 prevents long-term fibrotic kidney failure in cynomolgus monkeys
title_full Prophylactic orthosteric inhibition of leukocyte integrin CD11b/CD18 prevents long-term fibrotic kidney failure in cynomolgus monkeys
title_fullStr Prophylactic orthosteric inhibition of leukocyte integrin CD11b/CD18 prevents long-term fibrotic kidney failure in cynomolgus monkeys
title_full_unstemmed Prophylactic orthosteric inhibition of leukocyte integrin CD11b/CD18 prevents long-term fibrotic kidney failure in cynomolgus monkeys
title_sort prophylactic orthosteric inhibition of leukocyte integrin cd11b/cd18 prevents long-term fibrotic kidney failure in cynomolgus monkeys
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2017-01-01
description Acute kidney injury can progress to chronic kidney disease. Here Dehnadiet al. develop a post-ischaemic chronic kidney disease model in cynomolgus monkeys and show that prophylactic inhibition of CD11b/CD18 leukocyte receptor via a monoclonal antibody inhibits progression of kidney disease and fibrosis.
url https://doi.org/10.1038/ncomms13899
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AT abenedictcosimi prophylacticorthostericinhibitionofleukocyteintegrincd11bcd18preventslongtermfibrotickidneyfailureincynomolgusmonkeys
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