Expression of B-cell activating factor, a proliferating inducing ligand and its receptors in primary central nervous system lymphoma

Expression of B-cell activating factor, a proliferating inducing ligand and its receptors in primary central nervous system lymphoma

B-cell activating factor belonging to the tumor necrosis factor family (BAFF) and a proliferating inducing ligand (APRIL) might play an important role in the pathogenesis of systemic B-cell malignancies. However, the BAFF/APRIL system has not been systematically evaluated in primary central nervous...

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Main Authors: Tobias Birnbaum, Sigrid Langer, Sigrun Roeber, Louisa von Baumgarten, Andreas Straube
Format: Article
Language:English
Published: MDPI AG 2013-03-01
Series:Neurology International
Subjects:
PCNSL, BAFF, APRIL, TACI, BCMA
Online Access:http://www.pagepress.org/journals/index.php/ni/article/view/4503
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spelling doaj-d00e83398c9048a69b6c05a0b2beb0f32021-01-02T07:47:49ZengMDPI AGNeurology International2035-83852035-83772013-03-0151e4e410.4081/ni.2013.e42447Expression of B-cell activating factor, a proliferating inducing ligand and its receptors in primary central nervous system lymphomaTobias Birnbaum0Sigrid Langer1Sigrun Roeber2Louisa von Baumgarten3Andreas Straube4Department of Neurology, Ludwig-Maximilians University, MunichDepartment of Neurology, Ludwig-Maximilians University, MunichDepartment of Neuropathology, Ludwig-Maximilians University, MunichDepartment of Neurology, Ludwig-Maximilians University, MunichDepartment of Neurology, Ludwig-Maximilians University, MunichB-cell activating factor belonging to the tumor necrosis factor family (BAFF) and a proliferating inducing ligand (APRIL) might play an important role in the pathogenesis of systemic B-cell malignancies. However, the BAFF/APRIL system has not been systematically evaluated in primary central nervous system lymphoma (PCNSL) to date. We assessed the expression of BAFF, APRIL and its receptors BAFF-R (BAFF receptor), BCMA (B-cell maturation antigen) and TACI (transmembrane activator and calcium modulator cyclophilin ligand interactor) in five PCNSL specimens by immunohistochemical staining. We found extensive expression of BAFF and weak to moderate expression of APRIL, BAFF-R, BCMA, and TACI in all specimens. CD20 positive cells showed expression of both ligands and receptors at the same time. Our results indicate that autocrine stimulation of the BAFF/APRIL system might be involved in the pathogenesis of PCNSL.http://www.pagepress.org/journals/index.php/ni/article/view/4503PCNSL, BAFF, APRIL, TACI, BCMA
collection DOAJ
language English
format Article
sources DOAJ
author Tobias Birnbaum
Sigrid Langer
Sigrun Roeber
Louisa von Baumgarten
Andreas Straube
spellingShingle Tobias Birnbaum
Sigrid Langer
Sigrun Roeber
Louisa von Baumgarten
Andreas Straube
Expression of B-cell activating factor, a proliferating inducing ligand and its receptors in primary central nervous system lymphoma
Neurology International
PCNSL, BAFF, APRIL, TACI, BCMA
author_facet Tobias Birnbaum
Sigrid Langer
Sigrun Roeber
Louisa von Baumgarten
Andreas Straube
author_sort Tobias Birnbaum
title Expression of B-cell activating factor, a proliferating inducing ligand and its receptors in primary central nervous system lymphoma
title_short Expression of B-cell activating factor, a proliferating inducing ligand and its receptors in primary central nervous system lymphoma
title_full Expression of B-cell activating factor, a proliferating inducing ligand and its receptors in primary central nervous system lymphoma
title_fullStr Expression of B-cell activating factor, a proliferating inducing ligand and its receptors in primary central nervous system lymphoma
title_full_unstemmed Expression of B-cell activating factor, a proliferating inducing ligand and its receptors in primary central nervous system lymphoma
title_sort expression of b-cell activating factor, a proliferating inducing ligand and its receptors in primary central nervous system lymphoma
publisher MDPI AG
series Neurology International
issn 2035-8385
2035-8377
publishDate 2013-03-01
description B-cell activating factor belonging to the tumor necrosis factor family (BAFF) and a proliferating inducing ligand (APRIL) might play an important role in the pathogenesis of systemic B-cell malignancies. However, the BAFF/APRIL system has not been systematically evaluated in primary central nervous system lymphoma (PCNSL) to date. We assessed the expression of BAFF, APRIL and its receptors BAFF-R (BAFF receptor), BCMA (B-cell maturation antigen) and TACI (transmembrane activator and calcium modulator cyclophilin ligand interactor) in five PCNSL specimens by immunohistochemical staining. We found extensive expression of BAFF and weak to moderate expression of APRIL, BAFF-R, BCMA, and TACI in all specimens. CD20 positive cells showed expression of both ligands and receptors at the same time. Our results indicate that autocrine stimulation of the BAFF/APRIL system might be involved in the pathogenesis of PCNSL.
topic PCNSL, BAFF, APRIL, TACI, BCMA
url http://www.pagepress.org/journals/index.php/ni/article/view/4503
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