Associations Between PET Parameters and Expression of Ki-67 in Breast Cancer
OBJECTIVES: Numerous studies investigated relationships between positron emission tomography and proliferation index Ki-67 in breast cancer (BC) with inconsistent results. The aim of the present analysis was to provide evident data about associations between standardized uptake value (SUV) and expre...
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doaj-d03511b805674b0889f135620a6ac4d32020-11-24T23:21:24ZengElsevierTranslational Oncology1936-52332019-02-01122375380Associations Between PET Parameters and Expression of Ki-67 in Breast CancerAlexey Surov0Hans Jonas Meyer1Andreas Wienke2Department of Diagnostic and Interventional Radiology, University of Leipzig, Liebigstr. 20, 04103 Leipzig, Germany; Address all correspondence to: Dr. Alexey Surov, Department of Diagnostic and Interventional Radiology, University of Leipzig, Liebigstr. 20, 04103 Leipzig, Germany.Department of Diagnostic and Interventional Radiology, University of Leipzig, Liebigstr. 20, 04103 Leipzig, GermanyInstitute of Medical Epidemiology, Biostatistics, and Informatics, Martin-Luther-University Halle-Wittenberg, Magdeburger Str., 06097 Halle, GermanyOBJECTIVES: Numerous studies investigated relationships between positron emission tomography and proliferation index Ki-67 in breast cancer (BC) with inconsistent results. The aim of the present analysis was to provide evident data about associations between standardized uptake value (SUV) and expression of Ki-67 in BC. METHODS: MEDLINE library, SCOPUS and EMBASE data bases were screened for relationships between SUV and Ki-67 in BC up to April 2018. Overall, 32 studies with 1802 patients were identified. The following data were extracted from the literature: authors, year of publication, number of patients, and correlation coefficients. Associations between SUV and Ki-67 were analyzed by Spearman's correlation coefficient. RESULTS: Associations between SUVmax derived from 18F-FDG PET and Ki-67 were reported in 25 studies (1624 patients). The pooled correlation coefficient was 0.40, (95% CI = [0.34; 0.46]). Furthermore, 7 studies analyzed associations between SUVmax derived from 18F-fluorthymidin (FLT) PET and Ki-67 (178 patients). The pooled correlation coefficient was 0.54, (95% CI = [0.37; 0.70]). CONCLUSION: SUVmax correlated moderately with expression of Ki-67 and, therefore, cannot be used as a surrogate marker for tumor proliferation. Further studies are needed to evaluate associations between PET parameters and histopathological findings like hormone receptor status in breast cancer.http://www.sciencedirect.com/science/article/pii/S193652331830411X |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Alexey Surov Hans Jonas Meyer Andreas Wienke |
spellingShingle |
Alexey Surov Hans Jonas Meyer Andreas Wienke Associations Between PET Parameters and Expression of Ki-67 in Breast Cancer Translational Oncology |
author_facet |
Alexey Surov Hans Jonas Meyer Andreas Wienke |
author_sort |
Alexey Surov |
title |
Associations Between PET Parameters and Expression of Ki-67 in Breast Cancer |
title_short |
Associations Between PET Parameters and Expression of Ki-67 in Breast Cancer |
title_full |
Associations Between PET Parameters and Expression of Ki-67 in Breast Cancer |
title_fullStr |
Associations Between PET Parameters and Expression of Ki-67 in Breast Cancer |
title_full_unstemmed |
Associations Between PET Parameters and Expression of Ki-67 in Breast Cancer |
title_sort |
associations between pet parameters and expression of ki-67 in breast cancer |
publisher |
Elsevier |
series |
Translational Oncology |
issn |
1936-5233 |
publishDate |
2019-02-01 |
description |
OBJECTIVES: Numerous studies investigated relationships between positron emission tomography and proliferation index Ki-67 in breast cancer (BC) with inconsistent results. The aim of the present analysis was to provide evident data about associations between standardized uptake value (SUV) and expression of Ki-67 in BC. METHODS: MEDLINE library, SCOPUS and EMBASE data bases were screened for relationships between SUV and Ki-67 in BC up to April 2018. Overall, 32 studies with 1802 patients were identified. The following data were extracted from the literature: authors, year of publication, number of patients, and correlation coefficients. Associations between SUV and Ki-67 were analyzed by Spearman's correlation coefficient. RESULTS: Associations between SUVmax derived from 18F-FDG PET and Ki-67 were reported in 25 studies (1624 patients). The pooled correlation coefficient was 0.40, (95% CI = [0.34; 0.46]). Furthermore, 7 studies analyzed associations between SUVmax derived from 18F-fluorthymidin (FLT) PET and Ki-67 (178 patients). The pooled correlation coefficient was 0.54, (95% CI = [0.37; 0.70]). CONCLUSION: SUVmax correlated moderately with expression of Ki-67 and, therefore, cannot be used as a surrogate marker for tumor proliferation. Further studies are needed to evaluate associations between PET parameters and histopathological findings like hormone receptor status in breast cancer. |
url |
http://www.sciencedirect.com/science/article/pii/S193652331830411X |
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