Non-specific dsRNA-mediated antiviral response in the honey bee.
Honey bees are essential pollinators of numerous agricultural crops. Since 2006, honey bee populations have suffered considerable annual losses that are partially attributed to Colony Collapse Disorder (CCD). CCD is an unexplained phenomenon that correlates with elevated incidence of pathogens, incl...
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doaj-d039ac43e50d4a6d98fa6c97befb997e2020-11-25T00:24:21ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-01810e7726310.1371/journal.pone.0077263Non-specific dsRNA-mediated antiviral response in the honey bee.Michelle L FlennikenRaul AndinoHoney bees are essential pollinators of numerous agricultural crops. Since 2006, honey bee populations have suffered considerable annual losses that are partially attributed to Colony Collapse Disorder (CCD). CCD is an unexplained phenomenon that correlates with elevated incidence of pathogens, including RNA viruses. Honey bees are eusocial insects that live in colonies of genetically related individuals that work in concert to gather and store nutrients. Their social organization provides numerous benefits, but also facilitates pathogen transmission between individuals. To investigate honey bee antiviral defense mechanisms, we developed an RNA virus infection model and discovered that administration of dsRNA, regardless of sequence, reduced virus infection. Our results suggest that dsRNA, a viral pathogen associated molecular pattern (PAMP), triggers an antiviral response that controls virus infection in honey bees.http://europepmc.org/articles/PMC3795074?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Michelle L Flenniken Raul Andino |
spellingShingle |
Michelle L Flenniken Raul Andino Non-specific dsRNA-mediated antiviral response in the honey bee. PLoS ONE |
author_facet |
Michelle L Flenniken Raul Andino |
author_sort |
Michelle L Flenniken |
title |
Non-specific dsRNA-mediated antiviral response in the honey bee. |
title_short |
Non-specific dsRNA-mediated antiviral response in the honey bee. |
title_full |
Non-specific dsRNA-mediated antiviral response in the honey bee. |
title_fullStr |
Non-specific dsRNA-mediated antiviral response in the honey bee. |
title_full_unstemmed |
Non-specific dsRNA-mediated antiviral response in the honey bee. |
title_sort |
non-specific dsrna-mediated antiviral response in the honey bee. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2013-01-01 |
description |
Honey bees are essential pollinators of numerous agricultural crops. Since 2006, honey bee populations have suffered considerable annual losses that are partially attributed to Colony Collapse Disorder (CCD). CCD is an unexplained phenomenon that correlates with elevated incidence of pathogens, including RNA viruses. Honey bees are eusocial insects that live in colonies of genetically related individuals that work in concert to gather and store nutrients. Their social organization provides numerous benefits, but also facilitates pathogen transmission between individuals. To investigate honey bee antiviral defense mechanisms, we developed an RNA virus infection model and discovered that administration of dsRNA, regardless of sequence, reduced virus infection. Our results suggest that dsRNA, a viral pathogen associated molecular pattern (PAMP), triggers an antiviral response that controls virus infection in honey bees. |
url |
http://europepmc.org/articles/PMC3795074?pdf=render |
work_keys_str_mv |
AT michellelflenniken nonspecificdsrnamediatedantiviralresponseinthehoneybee AT raulandino nonspecificdsrnamediatedantiviralresponseinthehoneybee |
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1725352467003080704 |