Development of Chitosan/Silver Sulfadiazine/Zeolite Composite Films for Wound Dressing
Biopolymeric films with silver sulfadiazine (AgSD) are proposed as an alternative to the occlusive AgSD-containing creams and gauzes, which are commonly used in the treatment of conventional burns. While the recognized cytotoxicity of AgSD has been reported to compromise its use as an antimicrobial...
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doaj-d03a46ce07054a5785b40cca5016f2e12020-11-25T02:16:16ZengMDPI AGPharmaceutics1999-49232019-10-01111053510.3390/pharmaceutics11100535pharmaceutics11100535Development of Chitosan/Silver Sulfadiazine/Zeolite Composite Films for Wound DressingPatricia Hissae Yassue-Cordeiro0Cássio Henrique Zandonai1Bianca Pereira Genesi2Patrícia Santos Lopes3Elena Sanchez-Lopez4Maria Luisa Garcia5Nádia Regina Camargo Fernandes-Machado6Patrícia Severino7Eliana B. Souto8Classius Ferreira da Silva9Department of Chemical Engineering, Universidade Tecnológica Federal do Paraná, Av. dos Pioneiros, 3131, Jardim Morumbi, Londrina-PR 86036-370, BrazilDepartment of Chemical Engineering, Universidade Estadual de Maringá, Av. Colombo 5790 Bloco D-90, Maringá 87020-900, BrazilInstituto de Ciências Ambientais, Químicas e Farmacêuticas, Universidade Federal de São Paulo, Rua São Nicolau 210, Diadema 09913-030, BrazilInstituto de Ciências Ambientais, Químicas e Farmacêuticas, Universidade Federal de São Paulo, Rua São Nicolau 210, Diadema 09913-030, BrazilDepartment of Pharmacy, Pharmaceutical Technology and Physical Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona, Av. Joan XXIII 27–31, 08028 Barcelona, SpainDepartment of Pharmacy, Pharmaceutical Technology and Physical Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona, Av. Joan XXIII 27–31, 08028 Barcelona, SpainDepartment of Chemical Engineering, Universidade Tecnológica Federal do Paraná, Av. dos Pioneiros, 3131, Jardim Morumbi, Londrina-PR 86036-370, BrazilInstituto de Tecnologia e Pesquisa, Universidade Tiradentes, Aracaju 49010-390, BrazilFaculdade de Farmácia, Universidade de Coimbra, Pólo das Ciências da Saúde, Azinhaga de Santa Comba, 3000-548 Coimbra, PortugalInstituto de Ciências Ambientais, Químicas e Farmacêuticas, Universidade Federal de São Paulo, Rua São Nicolau 210, Diadema 09913-030, BrazilBiopolymeric films with silver sulfadiazine (AgSD) are proposed as an alternative to the occlusive AgSD-containing creams and gauzes, which are commonly used in the treatment of conventional burns. While the recognized cytotoxicity of AgSD has been reported to compromise its use as an antimicrobial drug in pharmaceuticals, this limitation can be overcome by developing sustained-release formulations. Microporous materials as zeolites can be used as drug delivery systems for sustained release of AgSD. The purpose of this work was the development and characterization of chitosan/zeolite composite films to be used as wound dressings. Zeolite was impregnated with AgSD before the production of the composite films. The physicochemical properties of zeolites and the films were evaluated, as well as the antimicrobial activity of the polymeric films and the cytotoxicity of the films in fibroblasts Balb 3T3/c. Impregnated zeolite exhibited changes in FTIR spectra and XRD diffraction patterns, in comparison to non-impregnated composites, which corroborate the results obtained with EDX-SEM. The pure chitosan film was compact and without noticeable defects and macropores, while the film with zeolite was opaquer, more rigid, and efficient against <i>Candida albicans</i> and some gram-negative bacteria. The safety evaluation showed that although the AgSD films present cytotoxicity, they could be used in a concentration-dependent fashion.https://www.mdpi.com/1999-4923/11/10/535wound dressingsilver sulfadiazinezeoliteschitosancomposite films |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Patricia Hissae Yassue-Cordeiro Cássio Henrique Zandonai Bianca Pereira Genesi Patrícia Santos Lopes Elena Sanchez-Lopez Maria Luisa Garcia Nádia Regina Camargo Fernandes-Machado Patrícia Severino Eliana B. Souto Classius Ferreira da Silva |
spellingShingle |
Patricia Hissae Yassue-Cordeiro Cássio Henrique Zandonai Bianca Pereira Genesi Patrícia Santos Lopes Elena Sanchez-Lopez Maria Luisa Garcia Nádia Regina Camargo Fernandes-Machado Patrícia Severino Eliana B. Souto Classius Ferreira da Silva Development of Chitosan/Silver Sulfadiazine/Zeolite Composite Films for Wound Dressing Pharmaceutics wound dressing silver sulfadiazine zeolites chitosan composite films |
author_facet |
Patricia Hissae Yassue-Cordeiro Cássio Henrique Zandonai Bianca Pereira Genesi Patrícia Santos Lopes Elena Sanchez-Lopez Maria Luisa Garcia Nádia Regina Camargo Fernandes-Machado Patrícia Severino Eliana B. Souto Classius Ferreira da Silva |
author_sort |
Patricia Hissae Yassue-Cordeiro |
title |
Development of Chitosan/Silver Sulfadiazine/Zeolite Composite Films for Wound Dressing |
title_short |
Development of Chitosan/Silver Sulfadiazine/Zeolite Composite Films for Wound Dressing |
title_full |
Development of Chitosan/Silver Sulfadiazine/Zeolite Composite Films for Wound Dressing |
title_fullStr |
Development of Chitosan/Silver Sulfadiazine/Zeolite Composite Films for Wound Dressing |
title_full_unstemmed |
Development of Chitosan/Silver Sulfadiazine/Zeolite Composite Films for Wound Dressing |
title_sort |
development of chitosan/silver sulfadiazine/zeolite composite films for wound dressing |
publisher |
MDPI AG |
series |
Pharmaceutics |
issn |
1999-4923 |
publishDate |
2019-10-01 |
description |
Biopolymeric films with silver sulfadiazine (AgSD) are proposed as an alternative to the occlusive AgSD-containing creams and gauzes, which are commonly used in the treatment of conventional burns. While the recognized cytotoxicity of AgSD has been reported to compromise its use as an antimicrobial drug in pharmaceuticals, this limitation can be overcome by developing sustained-release formulations. Microporous materials as zeolites can be used as drug delivery systems for sustained release of AgSD. The purpose of this work was the development and characterization of chitosan/zeolite composite films to be used as wound dressings. Zeolite was impregnated with AgSD before the production of the composite films. The physicochemical properties of zeolites and the films were evaluated, as well as the antimicrobial activity of the polymeric films and the cytotoxicity of the films in fibroblasts Balb 3T3/c. Impregnated zeolite exhibited changes in FTIR spectra and XRD diffraction patterns, in comparison to non-impregnated composites, which corroborate the results obtained with EDX-SEM. The pure chitosan film was compact and without noticeable defects and macropores, while the film with zeolite was opaquer, more rigid, and efficient against <i>Candida albicans</i> and some gram-negative bacteria. The safety evaluation showed that although the AgSD films present cytotoxicity, they could be used in a concentration-dependent fashion. |
topic |
wound dressing silver sulfadiazine zeolites chitosan composite films |
url |
https://www.mdpi.com/1999-4923/11/10/535 |
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