α-Synuclein Aggregated with Tau and β-Amyloid in Human Platelets from Healthy Subjects: Correlation with Physical Exercise

α-Synuclein Aggregated with Tau and β-Amyloid in Human Platelets from Healthy Subjects: Correlation with Physical Exercise

The loss of protein homeostasis that has been associated with aging leads to altered levels and conformational instability of proteins, which tend to form toxic aggregates. In particular, brain aging presents characteristic patterns of misfolded oligomers, primarily constituted of β-amyloid (Aβ), ta...

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Bibliographic Details
Main Authors: Simona Daniele, Deborah Pietrobono, Jonathan Fusi, Annalisa Lo Gerfo, Eugenio Cerri, Lucia Chico, Caterina Iofrida, Lucia Petrozzi, Filippo Baldacci, Chiara Giacomelli, Fabio Galetta, Gabriele Siciliano, Ubaldo Bonuccelli, Maria L. Trincavelli, Ferdinando Franzoni, Claudia Martini
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-01-01
Series:Frontiers in Aging Neuroscience
Subjects:
protein misfolding
α-synuclein
β-amyloid
tau
α-synuclein heterocomplexes
platelets
Online Access:http://journal.frontiersin.org/article/10.3389/fnagi.2018.00017/full

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