The Involvement of Microglial Cells in Japanese Encephalitis Infections

The Involvement of Microglial Cells in Japanese Encephalitis Infections

Despite the availability of effective vaccines, Japanese encephalitis virus (JEV) infections remain a leading cause of encephalitis in many Asian countries. The virus is transmitted to humans by Culex mosquitoes, and, while the majority of human infections are asymptomatic, up to 30% of JE cases adm...

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Main Authors: Thananya Thongtan, Chutima Thepparit, Duncan R. Smith
Format: Article
Language:English
Published: Hindawi Limited 2012-01-01
Series:Clinical and Developmental Immunology
Online Access:http://dx.doi.org/10.1155/2012/890586
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spelling doaj-d0736ef4ec1e4dc8bacab0249dc2b56e2020-11-25T01:10:15ZengHindawi LimitedClinical and Developmental Immunology1740-25221740-25302012-01-01201210.1155/2012/890586890586The Involvement of Microglial Cells in Japanese Encephalitis InfectionsThananya Thongtan0Chutima Thepparit1Duncan R. Smith2Department of Biochemistry, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, ThailandMolecular Pathology Laboratory, Institute of Molecular Biosciences, Mahidol University, Nakorn Pathom 73170, ThailandMolecular Pathology Laboratory, Institute of Molecular Biosciences, Mahidol University, Nakorn Pathom 73170, ThailandDespite the availability of effective vaccines, Japanese encephalitis virus (JEV) infections remain a leading cause of encephalitis in many Asian countries. The virus is transmitted to humans by Culex mosquitoes, and, while the majority of human infections are asymptomatic, up to 30% of JE cases admitted to hospital die and 50% of the survivors suffer from neurological sequelae. Microglia are brain-resident macrophages that play key roles in both the innate and adaptive immune responses in the CNS and are thus of importance in determining the pathology of encephalitis as a result of JEV infection.http://dx.doi.org/10.1155/2012/890586
collection DOAJ
language English
format Article
sources DOAJ
author Thananya Thongtan
Chutima Thepparit
Duncan R. Smith
spellingShingle Thananya Thongtan
Chutima Thepparit
Duncan R. Smith
The Involvement of Microglial Cells in Japanese Encephalitis Infections
Clinical and Developmental Immunology
author_facet Thananya Thongtan
Chutima Thepparit
Duncan R. Smith
author_sort Thananya Thongtan
title The Involvement of Microglial Cells in Japanese Encephalitis Infections
title_short The Involvement of Microglial Cells in Japanese Encephalitis Infections
title_full The Involvement of Microglial Cells in Japanese Encephalitis Infections
title_fullStr The Involvement of Microglial Cells in Japanese Encephalitis Infections
title_full_unstemmed The Involvement of Microglial Cells in Japanese Encephalitis Infections
title_sort involvement of microglial cells in japanese encephalitis infections
publisher Hindawi Limited
series Clinical and Developmental Immunology
issn 1740-2522
1740-2530
publishDate 2012-01-01
description Despite the availability of effective vaccines, Japanese encephalitis virus (JEV) infections remain a leading cause of encephalitis in many Asian countries. The virus is transmitted to humans by Culex mosquitoes, and, while the majority of human infections are asymptomatic, up to 30% of JE cases admitted to hospital die and 50% of the survivors suffer from neurological sequelae. Microglia are brain-resident macrophages that play key roles in both the innate and adaptive immune responses in the CNS and are thus of importance in determining the pathology of encephalitis as a result of JEV infection.
url http://dx.doi.org/10.1155/2012/890586
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