Association study of genetic variation of lncRNA MALAT1 with carcinogenesis of colorectal cancer

• Main Authors: Zhao K, Jin S, Wei B, Cao S, Xiong Z
• Format: Article
• Language: English
• Published: Dove Medical Press 2018-11-01
• Series: Cancer Management and Research
• Subjects: colorectal cancer; genetic; lncRNA; susceptibility; MALAT1
• Online Access: https://www.dovepress.com/association-study-of-genetic-variation-of-lncrna-malat1-with-carcinoge-peer-reviewed-article-CMAR

Kexin Zhao,1 Si Jin,2 Bo Wei,3 Shiqiong Cao,1 Zhifan Xiong1 1Division of Gastroenterology, Liyuan Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430077, People’s Republic of China; 2Department of Endocrinology, Liyuan Hospital, Tongji Medical College, Huazhong University of Science, Wuhan 430077, People’s Republic of China; 3Department of Oncology, Liyuan Hospital, Tongji Medical College, Huazhong University of Science, Wuhan 430077, People’s Republic of China Introduction: Colorectal cancer (CRC) remains a major public health concern worldwide. However, the detailed molecular mechanisms of CRC remain poorly understood. Methods: In the current study, we evaluated associations of four genetic variants located in the promoter and gene region of long noncoding RNAs metastasis-associated lung adenocarcinoma transcript 1 (lncRNA MALAT1) with CRC susceptibility among a Chinese population with 966 CRC cases and 988 healthy controls, using a two-stage, case–control study design (400 CRC cases and 400 controls in stage 1, and 566 CRC cases and 588 controls in stage 2). Results: We found that the minor alleles of rs619586 (OR=0.73; 95% CI=0.60–0.88; P=0.001) and rs1194338 (OR=0.80; 95% CI=0.70–0.92; P=0.001) were significantly associated with decreased CRC susceptibility. Compared with those with rs619586 −AA genotype, the risk of CRC was significantly lower in individuals with AG genotype (OR=0.76; 95% CI=0.61–0.95) and GG genotype (OR=0.46; 95% CI=0.23–0.90). Compared with those with rs1194338 −CC genotype, the risk of CRC was significantly lower in individuals with AC genotype (OR=0.79; 95% CI=0.65–0.95) and AA genotype (OR=0.68; 95% CI=0.51–0.89). Conclusion: Taken together, our findings provided strong evidence for the hypothesis that genetic variants in lncRNA MALAT1 might contribute to the carcinogenesis of CRC. Keywords: colorectal cancer, genetic, lncRNA, susceptibility, MALAT1