Heart failure is independently associated with white matter lesions: insights from the population‐based LIFE‐Adult Study
Abstract Aims White matter lesions (WML) are common structural alterations in the white matter of the brain and their prevalence increases with age. They are associated with cerebral ischaemia and cognitive dysfunction. Patients with heart failure (HF) are at risk for cognitive decline. We hypothesi...
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doaj-d07c7a657303487bb1aa7d899305f07b2021-03-31T03:15:45ZengWileyESC Heart Failure2055-58222021-02-018169770410.1002/ehf2.13166Heart failure is independently associated with white matter lesions: insights from the population‐based LIFE‐Adult StudyTina Stegmann0Mai L. Chu1Veronica A. Witte2Arno Villringer3Deniz Kumral4Steffi G. Riedel‐Heller5Susanne Roehr6Andreas Hagendorff7Ulrich Laufs8Markus Loeffler9Rolf Wachter10Samira Zeynalova11Clinic and Policlinic for Cardiology University Hospital Leipzig Leipzig GermanyUniversity of Leipzig, Institute for Medical Informatics, Statistics and Epidemiology (IMISE) Leipzig GermanyDepartment of Neurology Max Planck Institute for Human Cognitive and Brain Science Leipzig GermanyDepartment of Neurology Max Planck Institute for Human Cognitive and Brain Science Leipzig GermanyDepartment of Neurology Max Planck Institute for Human Cognitive and Brain Science Leipzig GermanyPublic Health Research Unit and Department of Social Medicine University of Leipzig Leipzig GermanyPublic Health Research Unit and Department of Social Medicine University of Leipzig Leipzig GermanyClinic and Policlinic for Cardiology University Hospital Leipzig Leipzig GermanyClinic and Policlinic for Cardiology University Hospital Leipzig Leipzig GermanyUniversity of Leipzig, Institute for Medical Informatics, Statistics and Epidemiology (IMISE) Leipzig GermanyClinic and Policlinic for Cardiology University Hospital Leipzig Leipzig GermanyClinic and Policlinic for Cardiology University Hospital Leipzig Leipzig GermanyAbstract Aims White matter lesions (WML) are common structural alterations in the white matter of the brain and their prevalence increases with age. They are associated with cerebral ischaemia and cognitive dysfunction. Patients with heart failure (HF) are at risk for cognitive decline. We hypothesized that the presence and duration of HF are associated with WML. Methods and results The LIFE‐Adult Study is a population‐based study of 10 000 residents of Leipzig, Germany. WML were quantitated in 2490 participants who additionally underwent cerebral MRI using the Fazekas score. Mean age was 64 years, and 46% were female; 2156 (86.6%) subjects had Fazekas score of 0–1, and 334 (13.4%) had Fazekas score of 2–3. Thirty participants had a medical history of HF, 1019 had hypertension, and 51 had a history of stroke. Median left ventricular ejection fraction of the participants with HF was 57% (interquartile ranges 54–62). Age, troponin T, NT‐proBNP, body mass index, history of acute myocardial infarction, stroke, HF, and diabetes were positively associated with WML in univariate analysis. On multivariate analysis, age, hypertension, stroke, and HF were independently associated with WML. The odd's ratio for the association of WML (Fazekas 2–3) with HF was 2.8 (95% CI 1.2–6.5; P = 0.019). WML increased with longer duration of HF (P = 0.036 for trend). Conclusions In addition to age, hypertension, and stroke, the prevalence and duration of HF are independently associated with WML. This observation sets the stage to investigate the prognostic value of WML in HF and the impact of HF therapies on WML.https://doi.org/10.1002/ehf2.13166Heart failureWhite matter lesionsCognitive impairmentMagnetic resonance imagingPopulation‐based study |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Tina Stegmann Mai L. Chu Veronica A. Witte Arno Villringer Deniz Kumral Steffi G. Riedel‐Heller Susanne Roehr Andreas Hagendorff Ulrich Laufs Markus Loeffler Rolf Wachter Samira Zeynalova |
spellingShingle |
Tina Stegmann Mai L. Chu Veronica A. Witte Arno Villringer Deniz Kumral Steffi G. Riedel‐Heller Susanne Roehr Andreas Hagendorff Ulrich Laufs Markus Loeffler Rolf Wachter Samira Zeynalova Heart failure is independently associated with white matter lesions: insights from the population‐based LIFE‐Adult Study ESC Heart Failure Heart failure White matter lesions Cognitive impairment Magnetic resonance imaging Population‐based study |
author_facet |
Tina Stegmann Mai L. Chu Veronica A. Witte Arno Villringer Deniz Kumral Steffi G. Riedel‐Heller Susanne Roehr Andreas Hagendorff Ulrich Laufs Markus Loeffler Rolf Wachter Samira Zeynalova |
author_sort |
Tina Stegmann |
title |
Heart failure is independently associated with white matter lesions: insights from the population‐based LIFE‐Adult Study |
title_short |
Heart failure is independently associated with white matter lesions: insights from the population‐based LIFE‐Adult Study |
title_full |
Heart failure is independently associated with white matter lesions: insights from the population‐based LIFE‐Adult Study |
title_fullStr |
Heart failure is independently associated with white matter lesions: insights from the population‐based LIFE‐Adult Study |
title_full_unstemmed |
Heart failure is independently associated with white matter lesions: insights from the population‐based LIFE‐Adult Study |
title_sort |
heart failure is independently associated with white matter lesions: insights from the population‐based life‐adult study |
publisher |
Wiley |
series |
ESC Heart Failure |
issn |
2055-5822 |
publishDate |
2021-02-01 |
description |
Abstract Aims White matter lesions (WML) are common structural alterations in the white matter of the brain and their prevalence increases with age. They are associated with cerebral ischaemia and cognitive dysfunction. Patients with heart failure (HF) are at risk for cognitive decline. We hypothesized that the presence and duration of HF are associated with WML. Methods and results The LIFE‐Adult Study is a population‐based study of 10 000 residents of Leipzig, Germany. WML were quantitated in 2490 participants who additionally underwent cerebral MRI using the Fazekas score. Mean age was 64 years, and 46% were female; 2156 (86.6%) subjects had Fazekas score of 0–1, and 334 (13.4%) had Fazekas score of 2–3. Thirty participants had a medical history of HF, 1019 had hypertension, and 51 had a history of stroke. Median left ventricular ejection fraction of the participants with HF was 57% (interquartile ranges 54–62). Age, troponin T, NT‐proBNP, body mass index, history of acute myocardial infarction, stroke, HF, and diabetes were positively associated with WML in univariate analysis. On multivariate analysis, age, hypertension, stroke, and HF were independently associated with WML. The odd's ratio for the association of WML (Fazekas 2–3) with HF was 2.8 (95% CI 1.2–6.5; P = 0.019). WML increased with longer duration of HF (P = 0.036 for trend). Conclusions In addition to age, hypertension, and stroke, the prevalence and duration of HF are independently associated with WML. This observation sets the stage to investigate the prognostic value of WML in HF and the impact of HF therapies on WML. |
topic |
Heart failure White matter lesions Cognitive impairment Magnetic resonance imaging Population‐based study |
url |
https://doi.org/10.1002/ehf2.13166 |
work_keys_str_mv |
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