A genome-wide association scan implicates DCHS2, RUNX2, GLI3, PAX1 and EDAR in human facial variation
Humans show great diversity in facial appearance and this variation is highly heritable. Here, Andres Ruiz-Linares and colleagues examined facial features in admixed Latin Americans and identify genome-wide associations for 14 facial traits, including four gene loci (RUNX2, GLI3, DCHS2 and PAX1) inf...
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2016-05-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms11616 |
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Article |
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DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Kaustubh Adhikari Macarena Fuentes-Guajardo Mirsha Quinto-Sánchez Javier Mendoza-Revilla Juan Camilo Chacón-Duque Victor Acuña-Alonzo Claudia Jaramillo William Arias Rodrigo Barquera Lozano Gastón Macín Pérez Jorge Gómez-Valdés Hugo Villamil-Ramírez Tábita Hunemeier Virginia Ramallo Caio C. Silva de Cerqueira Malena Hurtado Valeria Villegas Vanessa Granja Carla Gallo Giovanni Poletti Lavinia Schuler-Faccini Francisco M. Salzano Maria- Cátira Bortolini Samuel Canizales-Quinteros Michael Cheeseman Javier Rosique Gabriel Bedoya Francisco Rothhammer Denis Headon Rolando González-José David Balding Andrés Ruiz-Linares |
| spellingShingle |
Kaustubh Adhikari Macarena Fuentes-Guajardo Mirsha Quinto-Sánchez Javier Mendoza-Revilla Juan Camilo Chacón-Duque Victor Acuña-Alonzo Claudia Jaramillo William Arias Rodrigo Barquera Lozano Gastón Macín Pérez Jorge Gómez-Valdés Hugo Villamil-Ramírez Tábita Hunemeier Virginia Ramallo Caio C. Silva de Cerqueira Malena Hurtado Valeria Villegas Vanessa Granja Carla Gallo Giovanni Poletti Lavinia Schuler-Faccini Francisco M. Salzano Maria- Cátira Bortolini Samuel Canizales-Quinteros Michael Cheeseman Javier Rosique Gabriel Bedoya Francisco Rothhammer Denis Headon Rolando González-José David Balding Andrés Ruiz-Linares A genome-wide association scan implicates DCHS2, RUNX2, GLI3, PAX1 and EDAR in human facial variation Nature Communications |
| author_facet |
Kaustubh Adhikari Macarena Fuentes-Guajardo Mirsha Quinto-Sánchez Javier Mendoza-Revilla Juan Camilo Chacón-Duque Victor Acuña-Alonzo Claudia Jaramillo William Arias Rodrigo Barquera Lozano Gastón Macín Pérez Jorge Gómez-Valdés Hugo Villamil-Ramírez Tábita Hunemeier Virginia Ramallo Caio C. Silva de Cerqueira Malena Hurtado Valeria Villegas Vanessa Granja Carla Gallo Giovanni Poletti Lavinia Schuler-Faccini Francisco M. Salzano Maria- Cátira Bortolini Samuel Canizales-Quinteros Michael Cheeseman Javier Rosique Gabriel Bedoya Francisco Rothhammer Denis Headon Rolando González-José David Balding Andrés Ruiz-Linares |
| author_sort |
Kaustubh Adhikari |
| title |
A genome-wide association scan implicates DCHS2, RUNX2, GLI3, PAX1 and EDAR in human facial variation |
| title_short |
A genome-wide association scan implicates DCHS2, RUNX2, GLI3, PAX1 and EDAR in human facial variation |
| title_full |
A genome-wide association scan implicates DCHS2, RUNX2, GLI3, PAX1 and EDAR in human facial variation |
| title_fullStr |
A genome-wide association scan implicates DCHS2, RUNX2, GLI3, PAX1 and EDAR in human facial variation |
| title_full_unstemmed |
A genome-wide association scan implicates DCHS2, RUNX2, GLI3, PAX1 and EDAR in human facial variation |
| title_sort |
genome-wide association scan implicates dchs2, runx2, gli3, pax1 and edar in human facial variation |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2016-05-01 |
| description |
Humans show great diversity in facial appearance and this variation is highly heritable. Here, Andres Ruiz-Linares and colleagues examined facial features in admixed Latin Americans and identify genome-wide associations for 14 facial traits, including four gene loci (RUNX2, GLI3, DCHS2 and PAX1) influencing nose morphology. |
| url |
https://doi.org/10.1038/ncomms11616 |
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doaj-d07cc19f3fa148309d99800133b88ddc2021-05-11T11:09:42ZengNature Publishing GroupNature Communications2041-17232016-05-017111110.1038/ncomms11616A genome-wide association scan implicates DCHS2, RUNX2, GLI3, PAX1 and EDAR in human facial variationKaustubh Adhikari0Macarena Fuentes-Guajardo1Mirsha Quinto-Sánchez2Javier Mendoza-Revilla3Juan Camilo Chacón-Duque4Victor Acuña-Alonzo5Claudia Jaramillo6William Arias7Rodrigo Barquera Lozano8Gastón Macín Pérez9Jorge Gómez-Valdés10Hugo Villamil-Ramírez11Tábita Hunemeier12Virginia Ramallo13Caio C. Silva de Cerqueira14Malena Hurtado15Valeria Villegas16Vanessa Granja17Carla Gallo18Giovanni Poletti19Lavinia Schuler-Faccini20Francisco M. Salzano21Maria- Cátira Bortolini22Samuel Canizales-Quinteros23Michael Cheeseman24Javier Rosique25Gabriel Bedoya26Francisco Rothhammer27Denis Headon28Rolando González-José29David Balding30Andrés Ruiz-Linares31Department of Genetics, Evolution and Environment, UCL Genetics Institute, University College LondonDepartment of Genetics, Evolution and Environment, UCL Genetics Institute, University College LondonCentro Nacional Patagónico, CONICET, Unidad de Diversidad, Sistematica y EvolucionDepartment of Genetics, Evolution and Environment, UCL Genetics Institute, University College LondonDepartment of Genetics, Evolution and Environment, UCL Genetics Institute, University College LondonDepartment of Genetics, Evolution and Environment, UCL Genetics Institute, University College LondonGENMOL (Genética Molecular), Universidad de AntioquiaGENMOL (Genética Molecular), Universidad de AntioquiaLaboratorio de Genética Molecular, Escuela Nacional de Antropologia e HistoriaLaboratorio de Genética Molecular, Escuela Nacional de Antropologia e HistoriaDepartamento de Anatomía, Facultad de Medicina, Universidad Nacional Autónoma de México (UNAM)Unidad de Genómica de Poblaciones Aplicada a la Salud, Facultad de Química, UNAM-Instituto Nacional de Medicina GenómicaDepartamento de Genética, Universidade Federal do Rio Grande do SulCentro Nacional Patagónico, CONICET, Unidad de Diversidad, Sistematica y EvolucionCentro Nacional Patagónico, CONICET, Unidad de Diversidad, Sistematica y EvolucionLaboratorios de Investigación y Desarrollo, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano HerediaLaboratorios de Investigación y Desarrollo, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano HerediaLaboratorios de Investigación y Desarrollo, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano HerediaLaboratorios de Investigación y Desarrollo, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano HerediaLaboratorios de Investigación y Desarrollo, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano HerediaDepartamento de Genética, Universidade Federal do Rio Grande do SulDepartamento de Genética, Universidade Federal do Rio Grande do SulDepartamento de Genética, Universidade Federal do Rio Grande do SulUnidad de Genómica de Poblaciones Aplicada a la Salud, Facultad de Química, UNAM-Instituto Nacional de Medicina GenómicaDivision of Developmental Biology, The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of EdinburghDepartamento de Antropología, Universidad de AntioquiaGENMOL (Genética Molecular), Universidad de AntioquiaInstituto de Alta Investigación, Universidad de TarapacáDivision of Developmental Biology, The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of EdinburghCentro Nacional Patagónico, CONICET, Unidad de Diversidad, Sistematica y EvolucionDepartment of Genetics, Evolution and Environment, UCL Genetics Institute, University College LondonDepartment of Genetics, Evolution and Environment, UCL Genetics Institute, University College LondonHumans show great diversity in facial appearance and this variation is highly heritable. Here, Andres Ruiz-Linares and colleagues examined facial features in admixed Latin Americans and identify genome-wide associations for 14 facial traits, including four gene loci (RUNX2, GLI3, DCHS2 and PAX1) influencing nose morphology.https://doi.org/10.1038/ncomms11616 |