Sex differences in redox homeostasis in renal disease

Sex differences in redox homeostasis in renal disease

Sex differences in redox signaling in the kidney present new challenges and opportunities for understanding the physiology and pathophysiology of the kidney. This review will focus on reactive oxygen species, immune-related signaling pathways and endothelin-1 as potential mediators of sex-difference...

Full description

Bibliographic Details
Main Authors: Tanecia Mitchell, Carmen De Miguel, Eman Y. Gohar
Format: Article
Language:English
Published: Elsevier 2020-04-01
Series:Redox Biology
Subjects:
Sex-differences
Redox signaling
Endothelin-1
ROS
Inflammation
Kidney
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231719314508
id doaj-d07e1202868d4b80a9214211b484b4fd
record_format Article
spelling doaj-d07e1202868d4b80a9214211b484b4fd2020-11-25T02:14:04ZengElsevierRedox Biology2213-23172020-04-0131Sex differences in redox homeostasis in renal diseaseTanecia Mitchell0Carmen De Miguel1Eman Y. Gohar2Department of Urology, University of Alabama at Birmingham, Birmingham, AL, USASection of Cardio-Renal Physiology & Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USASection of Cardio-Renal Physiology & Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA; Corresponding author. Section of Cardio-Renal Physiology & Medicine Division of Nephrology, Department of Medicine University of Alabama at Birmingham 720 20th St S, Kaul 840, Birmingham, AL, 35233, USA.Sex differences in redox signaling in the kidney present new challenges and opportunities for understanding the physiology and pathophysiology of the kidney. This review will focus on reactive oxygen species, immune-related signaling pathways and endothelin-1 as potential mediators of sex-differences in redox homeostasis in the kidney. Additionally, this review will highlight male-female differences in redox signaling in several major cardiovascular and renal disorders namely acute kidney injury, diabetic nephropathy, kidney stone disease and salt-sensitive hypertension. Furthermore, we will discuss the contribution of redox signaling in the pathogenesis of postmenopausal hypertension and preeclampsia.http://www.sciencedirect.com/science/article/pii/S2213231719314508Sex-differencesRedox signalingEndothelin-1ROSInflammationKidney
collection DOAJ
language English
format Article
sources DOAJ
author Tanecia Mitchell
Carmen De Miguel
Eman Y. Gohar
spellingShingle Tanecia Mitchell
Carmen De Miguel
Eman Y. Gohar
Sex differences in redox homeostasis in renal disease
Redox Biology
Sex-differences
Redox signaling
Endothelin-1
ROS
Inflammation
Kidney
author_facet Tanecia Mitchell
Carmen De Miguel
Eman Y. Gohar
author_sort Tanecia Mitchell
title Sex differences in redox homeostasis in renal disease
title_short Sex differences in redox homeostasis in renal disease
title_full Sex differences in redox homeostasis in renal disease
title_fullStr Sex differences in redox homeostasis in renal disease
title_full_unstemmed Sex differences in redox homeostasis in renal disease
title_sort sex differences in redox homeostasis in renal disease
publisher Elsevier
series Redox Biology
issn 2213-2317
publishDate 2020-04-01
description Sex differences in redox signaling in the kidney present new challenges and opportunities for understanding the physiology and pathophysiology of the kidney. This review will focus on reactive oxygen species, immune-related signaling pathways and endothelin-1 as potential mediators of sex-differences in redox homeostasis in the kidney. Additionally, this review will highlight male-female differences in redox signaling in several major cardiovascular and renal disorders namely acute kidney injury, diabetic nephropathy, kidney stone disease and salt-sensitive hypertension. Furthermore, we will discuss the contribution of redox signaling in the pathogenesis of postmenopausal hypertension and preeclampsia.
topic Sex-differences
Redox signaling
Endothelin-1
ROS
Inflammation
Kidney
url http://www.sciencedirect.com/science/article/pii/S2213231719314508
work_keys_str_mv AT taneciamitchell sexdifferencesinredoxhomeostasisinrenaldisease
AT carmendemiguel sexdifferencesinredoxhomeostasisinrenaldisease
AT emanygohar sexdifferencesinredoxhomeostasisinrenaldisease
_version_ 1724902169282347008

Similar Items