Capturing cell type-specific chromatin compartment patterns by applying topic modeling to single-cell Hi-C data.

Capturing cell type-specific chromatin compartment patterns by applying topic modeling to single-cell Hi-C data.

Single-cell Hi-C (scHi-C) interrogates genome-wide chromatin interaction in individual cells, allowing us to gain insights into 3D genome organization. However, the extremely sparse nature of scHi-C data poses a significant barrier to analysis, limiting our ability to tease out hidden biological inf...

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Bibliographic Details
Main Authors: Hyeon-Jin Kim, Galip Gürkan Yardımcı, Giancarlo Bonora, Vijay Ramani, Jie Liu, Ruolan Qiu, Choli Lee, Jennifer Hesson, Carol B Ware, Jay Shendure, Zhijun Duan, William Stafford Noble
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-09-01
Series:PLoS Computational Biology
Online Access:https://doi.org/10.1371/journal.pcbi.1008173

Internet

https://doi.org/10.1371/journal.pcbi.1008173

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