Integrin Targeted Therapeutics

Integrin Targeted Therapeutics

<p>Integrins are heterodimeric, transmembrane receptors that function as mechanosensors, adhesion molecules and signal transduction platforms in a multitude of biological processes. As such, integrins are central to the etiology and pathology of many disease states. Therefore, pharmacological...

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Main Author: Melissa Millard, Srinivas Odde, Nouri Neamati
Format: Article
Language:English
Published: Ivyspring International Publisher 2011-01-01
Series:Theranostics
Online Access:http://www.thno.org/v01p0154.htm
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spelling doaj-d088c92cbd2245ceb31135277e75b4712020-11-25T00:25:23ZengIvyspring International PublisherTheranostics1838-76402011-01-0111154188Integrin Targeted TherapeuticsMelissa Millard, Srinivas Odde, Nouri Neamati<p>Integrins are heterodimeric, transmembrane receptors that function as mechanosensors, adhesion molecules and signal transduction platforms in a multitude of biological processes. As such, integrins are central to the etiology and pathology of many disease states. Therefore, pharmacological inhibition of integrins is of great interest for the treatment and prevention of disease. In the last two decades several integrin-targeted drugs have made their way into clinical use, many others are in clinical trials and still more are showing promise as they advance through preclinical development. Herein, this review examines and evaluates the various drugs and compounds targeting integrins and the disease states in which they are implicated.</p>http://www.thno.org/v01p0154.htm
collection DOAJ
language English
format Article
sources DOAJ
author Melissa Millard, Srinivas Odde, Nouri Neamati
spellingShingle Melissa Millard, Srinivas Odde, Nouri Neamati
Integrin Targeted Therapeutics
Theranostics
author_facet Melissa Millard, Srinivas Odde, Nouri Neamati
author_sort Melissa Millard, Srinivas Odde, Nouri Neamati
title Integrin Targeted Therapeutics
title_short Integrin Targeted Therapeutics
title_full Integrin Targeted Therapeutics
title_fullStr Integrin Targeted Therapeutics
title_full_unstemmed Integrin Targeted Therapeutics
title_sort integrin targeted therapeutics
publisher Ivyspring International Publisher
series Theranostics
issn 1838-7640
publishDate 2011-01-01
description <p>Integrins are heterodimeric, transmembrane receptors that function as mechanosensors, adhesion molecules and signal transduction platforms in a multitude of biological processes. As such, integrins are central to the etiology and pathology of many disease states. Therefore, pharmacological inhibition of integrins is of great interest for the treatment and prevention of disease. In the last two decades several integrin-targeted drugs have made their way into clinical use, many others are in clinical trials and still more are showing promise as they advance through preclinical development. Herein, this review examines and evaluates the various drugs and compounds targeting integrins and the disease states in which they are implicated.</p>
url http://www.thno.org/v01p0154.htm
work_keys_str_mv AT melissamillardsrinivasoddenourineamati integrintargetedtherapeutics
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