CDKAL1 rs7756992 is associated with diabetic retinopathy in a Chinese population with type 2 diabetes
Abstract Diabetic retinopathy (DR) is a major microvascular complication of diabetes. Susceptibility genes for type 2 diabetes may also impact the susceptibility of DR. This case-control study investigated the effects of 88 type 2 diabetes susceptibility loci on DR in a Chinese population with type...
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2017-08-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-017-09010-w |
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doaj-d0956d1c461c4ec38f48d346bc0d4a44 |
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Article |
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DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Danfeng Peng Jie Wang Rong Zhang Feng Jiang Claudia H. T. Tam Guozhi Jiang Tao Wang Miao Chen Jing Yan Shiyun Wang Dandan Yan Zhen He Ronald C. W. Ma Yuqian Bao Cheng Hu Weiping Jia |
| spellingShingle |
Danfeng Peng Jie Wang Rong Zhang Feng Jiang Claudia H. T. Tam Guozhi Jiang Tao Wang Miao Chen Jing Yan Shiyun Wang Dandan Yan Zhen He Ronald C. W. Ma Yuqian Bao Cheng Hu Weiping Jia CDKAL1 rs7756992 is associated with diabetic retinopathy in a Chinese population with type 2 diabetes Scientific Reports |
| author_facet |
Danfeng Peng Jie Wang Rong Zhang Feng Jiang Claudia H. T. Tam Guozhi Jiang Tao Wang Miao Chen Jing Yan Shiyun Wang Dandan Yan Zhen He Ronald C. W. Ma Yuqian Bao Cheng Hu Weiping Jia |
| author_sort |
Danfeng Peng |
| title |
CDKAL1 rs7756992 is associated with diabetic retinopathy in a Chinese population with type 2 diabetes |
| title_short |
CDKAL1 rs7756992 is associated with diabetic retinopathy in a Chinese population with type 2 diabetes |
| title_full |
CDKAL1 rs7756992 is associated with diabetic retinopathy in a Chinese population with type 2 diabetes |
| title_fullStr |
CDKAL1 rs7756992 is associated with diabetic retinopathy in a Chinese population with type 2 diabetes |
| title_full_unstemmed |
CDKAL1 rs7756992 is associated with diabetic retinopathy in a Chinese population with type 2 diabetes |
| title_sort |
cdkal1 rs7756992 is associated with diabetic retinopathy in a chinese population with type 2 diabetes |
| publisher |
Nature Publishing Group |
| series |
Scientific Reports |
| issn |
2045-2322 |
| publishDate |
2017-08-01 |
| description |
Abstract Diabetic retinopathy (DR) is a major microvascular complication of diabetes. Susceptibility genes for type 2 diabetes may also impact the susceptibility of DR. This case-control study investigated the effects of 88 type 2 diabetes susceptibility loci on DR in a Chinese population with type 2 diabetes performed in two stages. In stage 1, 88 SNPs were genotyped in 1,251 patients with type 2 diabetes, and we found that ADAMTS9-AS2 rs4607103, WFS1 rs10010131, CDKAL1 rs7756992, VPS26A rs1802295 and IDE-KIF11-HHEX rs1111875 were significantly associated with DR. The association between CDKAL1 rs7756992 and DR remained significant after Bonferroni correction for multiple comparisons (corrected P = 0.0492). Then, the effect of rs7756992 on DR were analysed in two independent cohorts for replication in stage 2. Cohort (1) consisted of 380 patients with DR and 613 patients with diabetes for ≥5 years but without DR. Cohort (2) consisted of 545 patients with DR and 929 patients with diabetes for ≥5 years but without DR. A meta-analysis combining the results of stage 1 and 2 revealed a significant association between rs7756992 and DR, with the minor allele A conferring a lower risk of DR (OR 0.824, 95% CI 0.743–0.914, P = 2.46 × 10−4). |
| url |
https://doi.org/10.1038/s41598-017-09010-w |
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doaj-d0956d1c461c4ec38f48d346bc0d4a442020-12-08T01:33:01ZengNature Publishing GroupScientific Reports2045-23222017-08-01711710.1038/s41598-017-09010-wCDKAL1 rs7756992 is associated with diabetic retinopathy in a Chinese population with type 2 diabetesDanfeng Peng0Jie Wang1Rong Zhang2Feng Jiang3Claudia H. T. Tam4Guozhi Jiang5Tao Wang6Miao Chen7Jing Yan8Shiyun Wang9Dandan Yan10Zhen He11Ronald C. W. Ma12Yuqian Bao13Cheng Hu14Weiping Jia15Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Centre for Diabetes, Shanghai Key Clinic Centre for Metabolic Diseases, Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People’s HospitalShanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Centre for Diabetes, Shanghai Key Clinic Centre for Metabolic Diseases, Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People’s HospitalShanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Centre for Diabetes, Shanghai Key Clinic Centre for Metabolic Diseases, Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People’s HospitalShanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Centre for Diabetes, Shanghai Key Clinic Centre for Metabolic Diseases, Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People’s HospitalDepartment of Medicine and Therapeutics, The Chinese University of Hong KongDepartment of Medicine and Therapeutics, The Chinese University of Hong KongShanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Centre for Diabetes, Shanghai Key Clinic Centre for Metabolic Diseases, Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People’s HospitalShanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Centre for Diabetes, Shanghai Key Clinic Centre for Metabolic Diseases, Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People’s HospitalShanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Centre for Diabetes, Shanghai Key Clinic Centre for Metabolic Diseases, Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People’s HospitalShanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Centre for Diabetes, Shanghai Key Clinic Centre for Metabolic Diseases, Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People’s HospitalShanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Centre for Diabetes, Shanghai Key Clinic Centre for Metabolic Diseases, Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People’s HospitalShanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Centre for Diabetes, Shanghai Key Clinic Centre for Metabolic Diseases, Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People’s HospitalDepartment of Medicine and Therapeutics, The Chinese University of Hong KongShanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Centre for Diabetes, Shanghai Key Clinic Centre for Metabolic Diseases, Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People’s HospitalShanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Centre for Diabetes, Shanghai Key Clinic Centre for Metabolic Diseases, Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People’s HospitalShanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Centre for Diabetes, Shanghai Key Clinic Centre for Metabolic Diseases, Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People’s HospitalAbstract Diabetic retinopathy (DR) is a major microvascular complication of diabetes. Susceptibility genes for type 2 diabetes may also impact the susceptibility of DR. This case-control study investigated the effects of 88 type 2 diabetes susceptibility loci on DR in a Chinese population with type 2 diabetes performed in two stages. In stage 1, 88 SNPs were genotyped in 1,251 patients with type 2 diabetes, and we found that ADAMTS9-AS2 rs4607103, WFS1 rs10010131, CDKAL1 rs7756992, VPS26A rs1802295 and IDE-KIF11-HHEX rs1111875 were significantly associated with DR. The association between CDKAL1 rs7756992 and DR remained significant after Bonferroni correction for multiple comparisons (corrected P = 0.0492). Then, the effect of rs7756992 on DR were analysed in two independent cohorts for replication in stage 2. Cohort (1) consisted of 380 patients with DR and 613 patients with diabetes for ≥5 years but without DR. Cohort (2) consisted of 545 patients with DR and 929 patients with diabetes for ≥5 years but without DR. A meta-analysis combining the results of stage 1 and 2 revealed a significant association between rs7756992 and DR, with the minor allele A conferring a lower risk of DR (OR 0.824, 95% CI 0.743–0.914, P = 2.46 × 10−4).https://doi.org/10.1038/s41598-017-09010-w |