Threshold Levels of Gfi1 Maintain E2A Activity for B Cell Commitment via Repression of Id1.
A regulatory circuit that controls myeloid versus B lymphoid cell fate in hematopoietic progenitors has been proposed, in which a network of the transcription factors Egr1/2, Nab, Gfi1 and PU.1 forms the core element. Here we show that a direct link between Gfi1, the transcription factor E2A and its...
Main Authors: | Jennifer Fraszczak, Anne Helness, Riyan Chen, Charles Vadnais, François Robert, Cyrus Khandanpour, Tarik Möröy |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2016-01-01
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Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC4965025?pdf=render |
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