Obesity prevention of synthetic polysaccharides in high-fat diet fed C57BL/6 mice
The effect of novel synthetic polysaccharides such as polydextrose and galactoglucomannan to host physiology has not been well studied. This study was conducted to test the impact of synthetic polysaccharides on lipid metabolism, antioxidant activity, and the composition of gut microbiota of mice fe...
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doaj-d097020253514f30aced4a508acbec842021-04-29T04:44:46ZengElsevierJournal of Functional Foods1756-46462015-08-0117563574Obesity prevention of synthetic polysaccharides in high-fat diet fed C57BL/6 miceHaisong Wang0Xue Tang1Maureen Jepkorir Cheserek2Yonghui Shi3Guowei Le4State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China; Key Laboratory of Tea Biochemistry & Biotechnology, School of Tea and Food Science, Anhui Agricultural University, Hefei 230036, ChinaState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China; Research Center of Food Nutrition and Functional Factors, School of Food Science and Technology, Jiangnan University, Wuxi 214122, ChinaResearch Center of Food Nutrition and Functional Factors, School of Food Science and Technology, Jiangnan University, Wuxi 214122, China; Human Nutrition Department, Egerton University, PO BOX 536, Njoro, KenyaState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China; Research Center of Food Nutrition and Functional Factors, School of Food Science and Technology, Jiangnan University, Wuxi 214122, ChinaState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China; Research Center of Food Nutrition and Functional Factors, School of Food Science and Technology, Jiangnan University, Wuxi 214122, China; Corresponding author. State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China. Tel.: +86 510 85917789; fax: +86 510 85917789.The effect of novel synthetic polysaccharides such as polydextrose and galactoglucomannan to host physiology has not been well studied. This study was conducted to test the impact of synthetic polysaccharides on lipid metabolism, antioxidant activity, and the composition of gut microbiota of mice fed with high-fat diet (HFD). The results showed that HFD supplemented with polysaccharides induced positive effects in relation to serum endotoxin, blood glucose, serum and liver lipids, decreased fat accumulation and Lee obesity index, and reduced liver adipose steatosis. Fifteen week treatment with polysaccharides significantly decreased the levels of reactive oxygen species (ROS) and thiobarbituric acid reactive substances (TBARS), and increased total antioxidant capacity and the activity of superoxide dismutase and glutathione peroxidase. The polysaccharides improved gut microbiota dysbiosis induced by HFD, including increasing the Bacteroidetes-to-Firmicutes ratios, significantly inhibiting the growth of Enterococcus faecalis, and promoting proliferation of Bifidobacteria and Lactobacilli. Furthermore, polysaccharides significantly increased the production of short chain fatty acids (SCFAs) in vitro. Thus, synthetic polysaccharides can be used as potential functional foods. Moreover, it can sufficiently decrease the risk of obesity and restore liver redox status under oxidative stress conditions mediated by HFD possibly by regulating gut microbes and increasing acetate, propionate, and butyrate.http://www.sciencedirect.com/science/article/pii/S1756464615002960Synthetic polysaccharidesHigh-fat dietAntioxidant capacityShort chain fatty acidsEndotoxin |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Haisong Wang Xue Tang Maureen Jepkorir Cheserek Yonghui Shi Guowei Le |
spellingShingle |
Haisong Wang Xue Tang Maureen Jepkorir Cheserek Yonghui Shi Guowei Le Obesity prevention of synthetic polysaccharides in high-fat diet fed C57BL/6 mice Journal of Functional Foods Synthetic polysaccharides High-fat diet Antioxidant capacity Short chain fatty acids Endotoxin |
author_facet |
Haisong Wang Xue Tang Maureen Jepkorir Cheserek Yonghui Shi Guowei Le |
author_sort |
Haisong Wang |
title |
Obesity prevention of synthetic polysaccharides in high-fat diet fed C57BL/6 mice |
title_short |
Obesity prevention of synthetic polysaccharides in high-fat diet fed C57BL/6 mice |
title_full |
Obesity prevention of synthetic polysaccharides in high-fat diet fed C57BL/6 mice |
title_fullStr |
Obesity prevention of synthetic polysaccharides in high-fat diet fed C57BL/6 mice |
title_full_unstemmed |
Obesity prevention of synthetic polysaccharides in high-fat diet fed C57BL/6 mice |
title_sort |
obesity prevention of synthetic polysaccharides in high-fat diet fed c57bl/6 mice |
publisher |
Elsevier |
series |
Journal of Functional Foods |
issn |
1756-4646 |
publishDate |
2015-08-01 |
description |
The effect of novel synthetic polysaccharides such as polydextrose and galactoglucomannan to host physiology has not been well studied. This study was conducted to test the impact of synthetic polysaccharides on lipid metabolism, antioxidant activity, and the composition of gut microbiota of mice fed with high-fat diet (HFD). The results showed that HFD supplemented with polysaccharides induced positive effects in relation to serum endotoxin, blood glucose, serum and liver lipids, decreased fat accumulation and Lee obesity index, and reduced liver adipose steatosis. Fifteen week treatment with polysaccharides significantly decreased the levels of reactive oxygen species (ROS) and thiobarbituric acid reactive substances (TBARS), and increased total antioxidant capacity and the activity of superoxide dismutase and glutathione peroxidase. The polysaccharides improved gut microbiota dysbiosis induced by HFD, including increasing the Bacteroidetes-to-Firmicutes ratios, significantly inhibiting the growth of Enterococcus faecalis, and promoting proliferation of Bifidobacteria and Lactobacilli. Furthermore, polysaccharides significantly increased the production of short chain fatty acids (SCFAs) in vitro. Thus, synthetic polysaccharides can be used as potential functional foods. Moreover, it can sufficiently decrease the risk of obesity and restore liver redox status under oxidative stress conditions mediated by HFD possibly by regulating gut microbes and increasing acetate, propionate, and butyrate. |
topic |
Synthetic polysaccharides High-fat diet Antioxidant capacity Short chain fatty acids Endotoxin |
url |
http://www.sciencedirect.com/science/article/pii/S1756464615002960 |
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