Ursolic acid treatment suppresses cuprizone-induced demyelination and motor dysfunction via upregulation of IGF-1

Ursolic acid treatment suppresses cuprizone-induced demyelination and motor dysfunction via upregulation of IGF-1

Multiple sclerosis (MS) is a demyelinating disease of the central nervous system, characterized by apoptotic death of mature oligodendrocytes, neuroinflammation, and motor dysfunction. A pentacyclic triterpenoid compound, ursolic acid (UA), has various pharmacological activities, such as anti-inflam...

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Main Authors: Shinji Yamamoto, Chiaki Sakemoto, Kensuke Iwasa, Kei Maruyama, Kuniyoshi Shimizu, Keisuke Yoshikawa
Format: Article
Language:English
Published: Elsevier 2020-11-01
Series:Journal of Pharmacological Sciences
Subjects:
Ursolic acid (UA)
Multiple sclerosis (MS)
Cuprizone (CPZ)
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861320300827
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spelling doaj-d0980910576a406c9c0c48b8457c7f812020-11-25T02:54:22ZengElsevierJournal of Pharmacological Sciences1347-86132020-11-011443119122Ursolic acid treatment suppresses cuprizone-induced demyelination and motor dysfunction via upregulation of IGF-1Shinji Yamamoto0Chiaki Sakemoto1Kensuke Iwasa2Kei Maruyama3Kuniyoshi Shimizu4Keisuke Yoshikawa5Department of Pharmacology, Faculty of Medicine, Saitama Medical University, 38 Moro-hongo, Moroyama-machi, Iruma-gun, Saitama 350-0495, Japan; School of Medical Technology, Faculty of Health and Medical Care, Saitama Medical University, 1397-1 Yamane, Hidaka-shi, Saitama 350-1241, JapanDepartment of Pharmacology, Faculty of Medicine, Saitama Medical University, 38 Moro-hongo, Moroyama-machi, Iruma-gun, Saitama 350-0495, Japan; School of Medical Technology, Faculty of Health and Medical Care, Saitama Medical University, 1397-1 Yamane, Hidaka-shi, Saitama 350-1241, JapanDepartment of Pharmacology, Faculty of Medicine, Saitama Medical University, 38 Moro-hongo, Moroyama-machi, Iruma-gun, Saitama 350-0495, JapanDepartment of Pharmacology, Faculty of Medicine, Saitama Medical University, 38 Moro-hongo, Moroyama-machi, Iruma-gun, Saitama 350-0495, JapanLaboratory of Systematic Forest and Forest Products Sciences, Division of Sustainable Bioresources Science, Department of Agro-Environmental Sciences, Faculty of Agriculture, Graduate School of Kyushu University, West Zone, Building 5, 744, Motooka, Nishi-ku, Fukuoka 819-0395, JapanDepartment of Pharmacology, Faculty of Medicine, Saitama Medical University, 38 Moro-hongo, Moroyama-machi, Iruma-gun, Saitama 350-0495, Japan; Corresponding author. Fax: +81 49 276 1585.Multiple sclerosis (MS) is a demyelinating disease of the central nervous system, characterized by apoptotic death of mature oligodendrocytes, neuroinflammation, and motor dysfunction. A pentacyclic triterpenoid compound, ursolic acid (UA), has various pharmacological activities, such as anti-inflammatory, anti-oxidative, and anti-apoptotic effects. In the present study, we investigated the effects of UA on cuprizone-induced demyelination, which is a model of MS. Oral administration of UA effectively suppressed cuprizone-induced demyelination and motor dysfunction via the enhancement of IGF-1 levels in the demyelinating lesions. Our results suggest that UA might be therapeutically useful for demyelination in MS.http://www.sciencedirect.com/science/article/pii/S1347861320300827Ursolic acid (UA)Multiple sclerosis (MS)Cuprizone (CPZ)
collection DOAJ
language English
format Article
sources DOAJ
author Shinji Yamamoto
Chiaki Sakemoto
Kensuke Iwasa
Kei Maruyama
Kuniyoshi Shimizu
Keisuke Yoshikawa
spellingShingle Shinji Yamamoto
Chiaki Sakemoto
Kensuke Iwasa
Kei Maruyama
Kuniyoshi Shimizu
Keisuke Yoshikawa
Ursolic acid treatment suppresses cuprizone-induced demyelination and motor dysfunction via upregulation of IGF-1
Journal of Pharmacological Sciences
Ursolic acid (UA)
Multiple sclerosis (MS)
Cuprizone (CPZ)
author_facet Shinji Yamamoto
Chiaki Sakemoto
Kensuke Iwasa
Kei Maruyama
Kuniyoshi Shimizu
Keisuke Yoshikawa
author_sort Shinji Yamamoto
title Ursolic acid treatment suppresses cuprizone-induced demyelination and motor dysfunction via upregulation of IGF-1
title_short Ursolic acid treatment suppresses cuprizone-induced demyelination and motor dysfunction via upregulation of IGF-1
title_full Ursolic acid treatment suppresses cuprizone-induced demyelination and motor dysfunction via upregulation of IGF-1
title_fullStr Ursolic acid treatment suppresses cuprizone-induced demyelination and motor dysfunction via upregulation of IGF-1
title_full_unstemmed Ursolic acid treatment suppresses cuprizone-induced demyelination and motor dysfunction via upregulation of IGF-1
title_sort ursolic acid treatment suppresses cuprizone-induced demyelination and motor dysfunction via upregulation of igf-1
publisher Elsevier
series Journal of Pharmacological Sciences
issn 1347-8613
publishDate 2020-11-01
description Multiple sclerosis (MS) is a demyelinating disease of the central nervous system, characterized by apoptotic death of mature oligodendrocytes, neuroinflammation, and motor dysfunction. A pentacyclic triterpenoid compound, ursolic acid (UA), has various pharmacological activities, such as anti-inflammatory, anti-oxidative, and anti-apoptotic effects. In the present study, we investigated the effects of UA on cuprizone-induced demyelination, which is a model of MS. Oral administration of UA effectively suppressed cuprizone-induced demyelination and motor dysfunction via the enhancement of IGF-1 levels in the demyelinating lesions. Our results suggest that UA might be therapeutically useful for demyelination in MS.
topic Ursolic acid (UA)
Multiple sclerosis (MS)
Cuprizone (CPZ)
url http://www.sciencedirect.com/science/article/pii/S1347861320300827
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