The Effect of Micronutrients on Pain Management of Primary Dysmenorrhea: a Systematic Review and Meta‐Analysis
Introduction: Primary dysmenorrhea is considered as one of the main problems in women. This review study aimed to characterize the effect of micronutrients on primary dysmenorrhea. Methods: In this systematic and meta‐analysis study, the articles were searched at Cochrane library, PubMed, Scopus, We...
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Tabriz University of Medical Sciences
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doaj-d09c8c762baa4957a3b01b09c19362b02020-11-25T02:27:49ZengTabriz University of Medical SciencesJournal of Caring Sciences2251-99202020-03-0191475610.34172/jcs.2020.008jcs-25575The Effect of Micronutrients on Pain Management of Primary Dysmenorrhea: a Systematic Review and Meta‐AnalysisMarzieh Saei Ghare Naz0Zahra Kiani1Farzaneh Rashidi Fakari2Vida Ghasemi3Masoumeh Abed4Giti Ozgoli5Department of Midwifery, Student Research Committee, School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, IranDepartment of Midwifery, Midwifery and Reproductive Health Research Center, Shahid Beheshti University of Medical Sciences, Tehran, IranDepartment of Midwifery, Midwifery and Reproductive Health Research Center, Shahid Beheshti University of Medical Sciences, Tehran, IranDepartment of Midwifery, Midwifery and Reproductive Health Research Center, Shahid Beheshti University of Medical Sciences, Tehran, IranDepartment of Gynecology and Obstetrics, School of Medicine, Alborz University of Medical Sciences, Alborz, IranDepartment of Midwifery, School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, IranIntroduction: Primary dysmenorrhea is considered as one of the main problems in women. This review study aimed to characterize the effect of micronutrients on primary dysmenorrhea. Methods: In this systematic and meta‐analysis study, the articles were searched at Cochrane library, PubMed, Scopus, Web of Science databases. The searching process was conducted with the key terms related to dysmenorrhea and micronutrients. Risk of bias assessment was performed, using Rev Man 5.3 software. In view of the heterogeneity of some of the studies, they were analyzed, using a qualitative method (n=10), and only 6 studies were included in Meta analyze. STATA statistical software version 11 was used for the analysis. Results: In this study, finally 16 clinical trials were investigated. Most micronutrients studied in the relevant articles had anti-inflammatory and analgesic properties with a desirable effect on dysmenorrhea pain relief. Vitamins (K, D, B1, and E) and calcium, magnesium, zinc sulfate and boron contributed effectively to dysmenorrhea pain management. Two months after the intervention, there was a significant mean decrease in the pain score for the vitamin D intervention group (SMD: -1.02, 95% CI: -1.9 to – 0.14, P =0.024) , as well as in the vitamin E intervention group compared to placebo group (SMD: - 0.47,95% CI:-0.74 to – 0.2, P = 0.001). Conclusion: Despite the paucity of related research, the studies indicated the potential effects of micronutrients on reducing the pain severity in primary dysmenorrhea. But more studies are needed to confirm the safety and effectiveness of various types of micronutrients on primary dysmenorrhea.https://jcs.tbzmed.ac.ir/PDF/jcs-25575micronutrientsvitaminsmineralsdysmenorrheasystematic review |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Marzieh Saei Ghare Naz Zahra Kiani Farzaneh Rashidi Fakari Vida Ghasemi Masoumeh Abed Giti Ozgoli |
spellingShingle |
Marzieh Saei Ghare Naz Zahra Kiani Farzaneh Rashidi Fakari Vida Ghasemi Masoumeh Abed Giti Ozgoli The Effect of Micronutrients on Pain Management of Primary Dysmenorrhea: a Systematic Review and Meta‐Analysis Journal of Caring Sciences micronutrients vitamins minerals dysmenorrhea systematic review |
author_facet |
Marzieh Saei Ghare Naz Zahra Kiani Farzaneh Rashidi Fakari Vida Ghasemi Masoumeh Abed Giti Ozgoli |
author_sort |
Marzieh Saei Ghare Naz |
title |
The Effect of Micronutrients on Pain Management of Primary Dysmenorrhea: a Systematic Review and Meta‐Analysis |
title_short |
The Effect of Micronutrients on Pain Management of Primary Dysmenorrhea: a Systematic Review and Meta‐Analysis |
title_full |
The Effect of Micronutrients on Pain Management of Primary Dysmenorrhea: a Systematic Review and Meta‐Analysis |
title_fullStr |
The Effect of Micronutrients on Pain Management of Primary Dysmenorrhea: a Systematic Review and Meta‐Analysis |
title_full_unstemmed |
The Effect of Micronutrients on Pain Management of Primary Dysmenorrhea: a Systematic Review and Meta‐Analysis |
title_sort |
effect of micronutrients on pain management of primary dysmenorrhea: a systematic review and meta‐analysis |
publisher |
Tabriz University of Medical Sciences |
series |
Journal of Caring Sciences |
issn |
2251-9920 |
publishDate |
2020-03-01 |
description |
Introduction: Primary dysmenorrhea is considered as one of the main problems in women. This review study aimed to characterize the effect of micronutrients on primary dysmenorrhea. Methods: In this systematic and meta‐analysis study, the articles were searched at Cochrane library, PubMed, Scopus, Web of Science databases. The searching process was conducted with the key terms related to dysmenorrhea and micronutrients. Risk of bias assessment was performed, using Rev Man 5.3 software. In view of the heterogeneity of some of the studies, they were analyzed, using a qualitative method (n=10), and only 6 studies were included in Meta analyze. STATA statistical software version 11 was used for the analysis. Results: In this study, finally 16 clinical trials were investigated. Most micronutrients studied in the relevant articles had anti-inflammatory and analgesic properties with a desirable effect on dysmenorrhea pain relief. Vitamins (K, D, B1, and E) and calcium, magnesium, zinc sulfate and boron contributed effectively to dysmenorrhea pain management. Two months after the intervention, there was a significant mean decrease in the pain score for the vitamin D intervention group (SMD: -1.02, 95% CI: -1.9 to – 0.14, P =0.024) , as well as in the vitamin E intervention group compared to placebo group (SMD: - 0.47,95% CI:-0.74 to – 0.2, P = 0.001). Conclusion: Despite the paucity of related research, the studies indicated the potential effects of micronutrients on reducing the pain severity in primary dysmenorrhea. But more studies are needed to confirm the safety and effectiveness of various types of micronutrients on primary dysmenorrhea. |
topic |
micronutrients vitamins minerals dysmenorrhea systematic review |
url |
https://jcs.tbzmed.ac.ir/PDF/jcs-25575 |
work_keys_str_mv |
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