Effector functions of eosinophils in schistosomiasis
The dual function of eosinophils is clearly illustred in schistosomiasis. Well equipped in membrane receptors for immunoglobulins and complement, and due to the presence of granule basic proteins, eosinophils can become cytotoxic for parasite larvae and thus participate to protective immunity. Howev...
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Instituto Oswaldo Cruz, Ministério da Saúde
1992-01-01
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doaj-d09c996d27f34538b2e655d2eaf91d642020-11-24T21:13:39ZengInstituto Oswaldo Cruz, Ministério da SaúdeMemórias do Instituto Oswaldo Cruz.0074-02761678-80601992-01-018716717010.1590/S0074-02761992000800025Effector functions of eosinophils in schistosomiasisMonique CapronAndré CapronThe dual function of eosinophils is clearly illustred in schistosomiasis. Well equipped in membrane receptors for immunoglobulins and complement, and due to the presence of granule basic proteins, eosinophils can become cytotoxic for parasite larvae and thus participate to protective immunity. However mediators can also exert their cytolytic effect on normal cells or tissues, inducing therefore pathology. Through ADCC mechanisms against schistosome larvae in vitro involving different antibody isotypes (IgG, IgE and IgA) and also in experiments performed in vivo, eosinophils have been clearly involved in protective immunity. Although no direct evidence of the protective role of eosinophils were brought in humans, the striking association of eosinophil-dependent cytotoxic antibody isotypes with resistance to reinfection (for instance IgE and IgA antibodies), whereas in vitro blocking antibody isotypes (IgG4, IgM) were detected in susceptible subjects, strongly, suggested the participation of eosinophils in antibody-dependent protective immune response. However eosinophils could also participate to granuloma formation around S. mansoni eggs and consequently to the pathological reactions induced by schistosomiasis.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761992000800025eosinophilsschistosomiasisimmunoglobulinsisotypic selectionprotectiontissue damage |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Monique Capron André Capron |
spellingShingle |
Monique Capron André Capron Effector functions of eosinophils in schistosomiasis Memórias do Instituto Oswaldo Cruz. eosinophils schistosomiasis immunoglobulins isotypic selection protection tissue damage |
author_facet |
Monique Capron André Capron |
author_sort |
Monique Capron |
title |
Effector functions of eosinophils in schistosomiasis |
title_short |
Effector functions of eosinophils in schistosomiasis |
title_full |
Effector functions of eosinophils in schistosomiasis |
title_fullStr |
Effector functions of eosinophils in schistosomiasis |
title_full_unstemmed |
Effector functions of eosinophils in schistosomiasis |
title_sort |
effector functions of eosinophils in schistosomiasis |
publisher |
Instituto Oswaldo Cruz, Ministério da Saúde |
series |
Memórias do Instituto Oswaldo Cruz. |
issn |
0074-0276 1678-8060 |
publishDate |
1992-01-01 |
description |
The dual function of eosinophils is clearly illustred in schistosomiasis. Well equipped in membrane receptors for immunoglobulins and complement, and due to the presence of granule basic proteins, eosinophils can become cytotoxic for parasite larvae and thus participate to protective immunity. However mediators can also exert their cytolytic effect on normal cells or tissues, inducing therefore pathology. Through ADCC mechanisms against schistosome larvae in vitro involving different antibody isotypes (IgG, IgE and IgA) and also in experiments performed in vivo, eosinophils have been clearly involved in protective immunity. Although no direct evidence of the protective role of eosinophils were brought in humans, the striking association of eosinophil-dependent cytotoxic antibody isotypes with resistance to reinfection (for instance IgE and IgA antibodies), whereas in vitro blocking antibody isotypes (IgG4, IgM) were detected in susceptible subjects, strongly, suggested the participation of eosinophils in antibody-dependent protective immune response. However eosinophils could also participate to granuloma formation around S. mansoni eggs and consequently to the pathological reactions induced by schistosomiasis. |
topic |
eosinophils schistosomiasis immunoglobulins isotypic selection protection tissue damage |
url |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761992000800025 |
work_keys_str_mv |
AT moniquecapron effectorfunctionsofeosinophilsinschistosomiasis AT andrecapron effectorfunctionsofeosinophilsinschistosomiasis |
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