Insight into a Novel p53 Single Point Mutation (G389E) by Molecular Dynamics Simulations

Insight into a Novel p53 Single Point Mutation (G389E) by Molecular Dynamics Simulations

The majority of inactivating mutations of p53 reside in the central core DNA binding domain of the protein. In this computational study, we investigated the structural effects of a novel p53 mutation (G389E), identified in a patient with congenital adrenal hyperplasia, which is located within the ex...

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Bibliographic Details
Main Authors: Maria Cristina De Rosa, Bruno Giardina, Paola Concolino, Cristiana Carelli Alinovi, Maria Antonia Satta, Ettore Capoluongo, Davide Pirolli
Format: Article
Language:English
Published: MDPI AG 2010-12-01
Series:International Journal of Molecular Sciences
Subjects:
p53
molecular dynamics
S100B
protein interactions
Online Access:http://www.mdpi.com/1422-0067/12/1/128/

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