Cullin-5 neddylation-mediated NOXA degradation is enhanced by PRDX1 oligomers in colorectal cancer

Cullin-5 neddylation-mediated NOXA degradation is enhanced by PRDX1 oligomers in colorectal cancer

Abstract NOXA, a BH3-only proapoptotic protein involved in regulating cell death decisions, is highly expressed but short-lived in colorectal cancer (CRC). Neddylated cullin-5 (CUL5)-mediated ubiquitination and degradation of NOXA is crucial to prevent its overaccumulation and maintain an appropriat...

Full description

Bibliographic Details
Main Authors:	Shoufang Xu, Yilei Ma, Qingchao Tong, Jun Yang, Jia Liu, Yanzhong Wang, Guoli Li, Jin Zeng, Sining Fang, Fengying Li, Xinyou Xie, Jun Zhang
Format:	Article
Language:	English
Published:	Nature Publishing Group 2021-03-01
Series:	Cell Death and Disease
Online Access:	https://doi.org/10.1038/s41419-021-03557-3

Similar Items

Correction: Cullin-5 neddylation-mediated NOXA degradation is enhanced by PRDX1 oligomers in colorectal cancer
by: Shoufang Xu, et al.
Published: (2021-04-01)

Anticancer drug discovery by targeting cullin neddylation
by: Qing Yu, et al.
Published: (2020-05-01)

Actions of Adenosine on Cullin Neddylation: Implications for Inflammatory Responses
by: Valerie F. Curtis, et al.
Published: (2015-01-01)

The discovery of a reciprocal relationship between tyrosine-kinase signaling and cullin neddylation.
by: Samantha F Friend, et al.
Published: (2013-01-01)

Targeting Cullin-RING E3 Ligases for Radiosensitization: From NEDDylation Inhibition to PROTACs
by: Shuhua Zheng, et al.
Published: (2020-08-01)

Proteasome lid bridges mitochondrial stress with Cdc53/Cullin1 NEDDylation status
by: L. Bramasole, et al.
Published: (2019-01-01)

Gossypol inhibits cullin neddylation by targeting SAG-CUL5 and RBX1-CUL1 complexes
by: Qing Yu, et al.
Published: (2020-04-01)

Curcumin Reverses NNMT-Induced 5-Fluorouracil Resistance via Increasing ROS and Cell Cycle Arrest in Colorectal Cancer Cells
by: Guoli Li, et al.
Published: (2021-08-01)

Targeting Protein Neddylation to Inactivate Cullin-RING Ligases by Gossypol: A Lucky Hit or a New Start?
by: Yu Q, et al.
Published: (2021-01-01)

TCTP and CSN4 control cell cycle progression and development by regulating CULLIN1 neddylation in plants and animals.
by: Léo Betsch, et al.
Published: (2019-01-01)

The role of Defective in Cullin Neddylation 1 Domain Containing 1 (DCUN1D1) in prostate cancer
by: Vava, Akhona
Published: (2014)

miR-148b-3p promotes migration of Schwann cells by targeting cullin-associated and neddylation-dissociated 1
by: Tian-mei Qian, et al.
Published: (2016-01-01)

SENP8 limits aberrant neddylation of NEDD8 pathway components to promote cullin-RING ubiquitin ligase function
by: Kate E Coleman, et al.
Published: (2017-05-01)

A potent small-molecule inhibitor of the DCN1-UBC12 interaction that selectively blocks cullin 3 neddylation
by: Haibin Zhou, et al.
Published: (2017-10-01)

UBXN7 docks on neddylated cullin complexes using its UIM motif and causes HIF1α accumulation
by: Bandau Susanne, et al.
Published: (2012-04-01)

PRDX2 promotes the proliferation of colorectal cancer cells by increasing the ubiquitinated degradation of p53
by: Wuyi Wang, et al.
Published: (2021-06-01)

Chemogenomic Study of Carboplatin in Saccharomyces cerevisiae: Inhibition of the NEDDylation Process Overcomes Cellular Resistance Mediated by HuR and Cullin Proteins.
by: Graziele Fonseca de Sousa, et al.
Published: (2015-01-01)

Selective inhibition of cullin 3 neddylation through covalent targeting DCN1 protects mice from acetaminophen-induced liver toxicity
by: Haibin Zhou, et al.
Published: (2021-05-01)

Expression of PRDX6 Correlates with Migration and Invasiveness of Colorectal Cancer Cells
by: Wen-Shih Huang, et al.
Published: (2018-12-01)

Exposure of Workers to Occupational Noxae
by: Sorin Simion, et al.
Published: (2021-01-01)

Korean Red Ginseng Extract Increases Apoptosis by Activation of the Noxa Pathway in Colorectal Cancer
by: Yoon A. Jeong, et al.
Published: (2019-08-01)

Neddylation dysfunction in Alzheimer's disease
by: Chen, Yuzhi, et al.
Published: (2014)

Neddylation Regulates Macrophages and Implications for Cancer Therapy
by: Yanyu Jiang, et al.
Published: (2021-06-01)

Global analysis of erythroid cells redox status reveals the involvement of Prdx1 and Prdx2 in the severity of beta thalassemia.
by: Karen S Romanello, et al.
Published: (2018-01-01)

Neddylation: a novel modulator of the tumor microenvironment
by: Lisha Zhou, et al.
Published: (2019-04-01)

Lgals9 deficiency ameliorates obesity by modulating redox state of PRDX2
by: Tomokazu Nunoue, et al.
Published: (2021-03-01)

NEDDylation promotes stress granule assembly
by: Aravinth Kumar Jayabalan, et al.
Published: (2016-07-01)

The pivotal roles of neddylation pathway in immunoregulation
by: Yun Lu, et al.
Published: (2020-12-01)

Ubiquitylation, neddylation and the DNA damage response
by: Jessica S. Brown, et al.
Published: (2015-01-01)

Neddylation Facilitates the Antiviral Response in Zebrafish
by: Guangqing Yu, et al.
Published: (2019-06-01)

Regulation of proteotoxicity through atypical NEDDylation
by: Maghames, Chantal
Published: (2016)

Neddylation regulation of mitochondrial structure and functions
by: Qiyin Zhou, et al.
Published: (2021-03-01)

Diversification of the cullin family
by: Marín Ignacio
Published: (2009-11-01)

Non-Mammalian Prdx6 Enzymes (Proteins with 1-Cys Prdx Mechanism) Display PLA2 Activity Similar to the Human Orthologue
by: Renata Bannitz-Fernandes, et al.
Published: (2019-03-01)

Neddylation, an Emerging Mechanism Regulating Cardiac Development and Function
by: Jie Li, et al.
Published: (2020-12-01)

Aspirin Induced Glioma Apoptosis through Noxa Upregulation
by: Cheng-Yi Chang, et al.
Published: (2020-06-01)

The regulatory roles of APE1 and Prdx1 interaction
by: Wang, Zhiqiang
Published: (2015)

The sumoylation and neddylation networks in Aspergillus nidulans development
by: Harting, Rebekka
Published: (2013)

Overactivated neddylation pathway in human hepatocellular carcinoma
by: Jian Yu, et al.
Published: (2018-07-01)

Advances in Cancer Treatment by Targeting the Neddylation Pathway
by: Wenbin Gai, et al.
Published: (2021-04-01)