One-pot synthesis of cyanohydrin derivatives from alkyl bromides via incorporation of two one-carbon components by consecutive radical/ionic reactions

One-pot synthesis of cyanohydrin derivatives from alkyl bromides via incorporation of two one-carbon components by consecutive radical/ionic reactions

The consecutive radical/ionic reaction consisting of radical formylation of alkyl bromides and nucleophilic addition of a cyanide ion was investigated, which gave moderate to good yields of cyanohydrin derivatives in one-pot.

Bibliographic Details
Main Authors: Shuhei Sumino, Akira Fusano, Hiroyuki Okai, Takahide Fukuyama, Ilhyong Ryu
Format: Article
Language:English
Published: Beilstein-Institut 2014-01-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
alkyl bromide
carbon monoxide
cyanohydrin
ethyl cyanoformate
multicomponent
radical reaction
Online Access:https://doi.org/10.3762/bjoc.10.12
Description
Summary:The consecutive radical/ionic reaction consisting of radical formylation of alkyl bromides and nucleophilic addition of a cyanide ion was investigated, which gave moderate to good yields of cyanohydrin derivatives in one-pot.
ISSN:1860-5397

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