Changes in Centrality Frequency of the Default Mode Network in Individuals With Subjective Cognitive Decline
Despite subjective cognitive decline (SCD), a preclinical stage of Alzheimer's disease (AD), being widely studied in recent years, studies on centrality frequency in individuals with SCD are lacking. This study aimed to investigate the differences in centrality frequency between individuals wit...
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doaj-d0ab1ba1a643442c868c718e109ac0382020-11-25T01:52:34ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652019-06-011110.3389/fnagi.2019.00118432438Changes in Centrality Frequency of the Default Mode Network in Individuals With Subjective Cognitive DeclineYunyan Xie0Tiantian Liu1Jing Ai2Duanduan Chen3Yiran Zhuo4Guanglei Zhao5Shuai He6Jinglong Wu7Ying Han8Ying Han9Ying Han10Ying Han11Tianyi Yan12Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, ChinaSchool of Life Science, Beijing Institute of Technology, Beijing, ChinaSchool of Life Science, Beijing Institute of Technology, Beijing, ChinaSchool of Life Science, Beijing Institute of Technology, Beijing, ChinaCollege of Electronic and Information Engineering, Tongji University, Shanghai, ChinaSchool of Life Science, Beijing Institute of Technology, Beijing, ChinaBeijing Haidian Foreign Language Shiyan School, Beijing, ChinaSchool of Mechatronical Engineering, Intelligent Robotics Institute, Beijing Institute of Technology, Beijing, ChinaDepartment of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, ChinaCenter of Alzheimer's Disease, Beijing Institute for Brain Disorders, Beijing, ChinaBeijing Institute of Geriatrics, Beijing, ChinaNational Clinical Research Center for Geriatric Disorders, Beijing, ChinaSchool of Life Science, Beijing Institute of Technology, Beijing, ChinaDespite subjective cognitive decline (SCD), a preclinical stage of Alzheimer's disease (AD), being widely studied in recent years, studies on centrality frequency in individuals with SCD are lacking. This study aimed to investigate the differences in centrality frequency between individuals with SCD and normal controls (NCs). Forty individuals with SCD and 53 well-matched NCs underwent a resting-state functional magnetic resonance imaging scan. We assessed individual dynamic functional connectivity using sliding window correlations. In each time window, brain regions with a high degree centrality were defined as hubs. Across the entire time window, the proportion of time that the hub appeared was characterized as centrality frequency. The centrality frequency correlated with cognitive performance differently in individuals with SCD and NCs. Our results revealed that in individuals with SCD, compared with NCs, correlations between centrality frequency of the anterior cortical regions and cognitive performance decreased (79.2% for NCs and 43.5% for individuals with SCD). In contrast, correlations between centrality frequency of the posterior cortical regions and cognitive performance increased in SCD individuals compared with NCs (20.8% for NCs and 56.5% for individuals with SCD). Moreover, the changes mainly focused on the anterior (93.3% for NCs and 45.5% for individuals with SCD) and posterior (6.7% for NCs and 54.5% for individuals with SCD) regions associated with the default mode network (DMN). In addition, we used absolute thresholds (correlation efficient r = 0.2, 0.25) and proportional thresholds (sparsity = 0.2, 0.25) to verify the results. Dynamic results are relative stable at absolute thresholds while static results are relative stable at proportional thresholds. Converging findings provide a new framework for the detection of the changes occurring in individuals with SCD via centrality frequency of the DMN.https://www.frontiersin.org/article/10.3389/fnagi.2019.00118/fullsubjective cognitive declinecentrality frequencyresting-state functional magnetic resonance imaginghub probabilitydefault mode network |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yunyan Xie Tiantian Liu Jing Ai Duanduan Chen Yiran Zhuo Guanglei Zhao Shuai He Jinglong Wu Ying Han Ying Han Ying Han Ying Han Tianyi Yan |
spellingShingle |
Yunyan Xie Tiantian Liu Jing Ai Duanduan Chen Yiran Zhuo Guanglei Zhao Shuai He Jinglong Wu Ying Han Ying Han Ying Han Ying Han Tianyi Yan Changes in Centrality Frequency of the Default Mode Network in Individuals With Subjective Cognitive Decline Frontiers in Aging Neuroscience subjective cognitive decline centrality frequency resting-state functional magnetic resonance imaging hub probability default mode network |
author_facet |
Yunyan Xie Tiantian Liu Jing Ai Duanduan Chen Yiran Zhuo Guanglei Zhao Shuai He Jinglong Wu Ying Han Ying Han Ying Han Ying Han Tianyi Yan |
author_sort |
Yunyan Xie |
title |
Changes in Centrality Frequency of the Default Mode Network in Individuals With Subjective Cognitive Decline |
title_short |
Changes in Centrality Frequency of the Default Mode Network in Individuals With Subjective Cognitive Decline |
title_full |
Changes in Centrality Frequency of the Default Mode Network in Individuals With Subjective Cognitive Decline |
title_fullStr |
Changes in Centrality Frequency of the Default Mode Network in Individuals With Subjective Cognitive Decline |
title_full_unstemmed |
Changes in Centrality Frequency of the Default Mode Network in Individuals With Subjective Cognitive Decline |
title_sort |
changes in centrality frequency of the default mode network in individuals with subjective cognitive decline |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Aging Neuroscience |
issn |
1663-4365 |
publishDate |
2019-06-01 |
description |
Despite subjective cognitive decline (SCD), a preclinical stage of Alzheimer's disease (AD), being widely studied in recent years, studies on centrality frequency in individuals with SCD are lacking. This study aimed to investigate the differences in centrality frequency between individuals with SCD and normal controls (NCs). Forty individuals with SCD and 53 well-matched NCs underwent a resting-state functional magnetic resonance imaging scan. We assessed individual dynamic functional connectivity using sliding window correlations. In each time window, brain regions with a high degree centrality were defined as hubs. Across the entire time window, the proportion of time that the hub appeared was characterized as centrality frequency. The centrality frequency correlated with cognitive performance differently in individuals with SCD and NCs. Our results revealed that in individuals with SCD, compared with NCs, correlations between centrality frequency of the anterior cortical regions and cognitive performance decreased (79.2% for NCs and 43.5% for individuals with SCD). In contrast, correlations between centrality frequency of the posterior cortical regions and cognitive performance increased in SCD individuals compared with NCs (20.8% for NCs and 56.5% for individuals with SCD). Moreover, the changes mainly focused on the anterior (93.3% for NCs and 45.5% for individuals with SCD) and posterior (6.7% for NCs and 54.5% for individuals with SCD) regions associated with the default mode network (DMN). In addition, we used absolute thresholds (correlation efficient r = 0.2, 0.25) and proportional thresholds (sparsity = 0.2, 0.25) to verify the results. Dynamic results are relative stable at absolute thresholds while static results are relative stable at proportional thresholds. Converging findings provide a new framework for the detection of the changes occurring in individuals with SCD via centrality frequency of the DMN. |
topic |
subjective cognitive decline centrality frequency resting-state functional magnetic resonance imaging hub probability default mode network |
url |
https://www.frontiersin.org/article/10.3389/fnagi.2019.00118/full |
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