Sarcosine Is Uniquely Modulated by Aging and Dietary Restriction in Rodents and Humans
Summary: A hallmark of aging is a decline in metabolic homeostasis, which is attenuated by dietary restriction (DR). However, the interaction of aging and DR with the metabolome is not well understood. We report that DR is a stronger modulator of the rat metabolome than age in plasma and tissues. A...
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Elsevier
2018-10-01
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Series: | Cell Reports |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124718315250 |
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Article |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ryan O. Walters Esperanza Arias Antonio Diaz Emmanuel S. Burgos Fangxia Guan Simoni Tiano Kai Mao Cara L. Green Yungping Qiu Hardik Shah Donghai Wang Adam D. Hudgins Tahmineh Tabrizian Valeria Tosti David Shechter Luigi Fontana Irwin J. Kurland Nir Barzilai Ana Maria Cuervo Daniel E.L. Promislow Derek M. Huffman |
spellingShingle |
Ryan O. Walters Esperanza Arias Antonio Diaz Emmanuel S. Burgos Fangxia Guan Simoni Tiano Kai Mao Cara L. Green Yungping Qiu Hardik Shah Donghai Wang Adam D. Hudgins Tahmineh Tabrizian Valeria Tosti David Shechter Luigi Fontana Irwin J. Kurland Nir Barzilai Ana Maria Cuervo Daniel E.L. Promislow Derek M. Huffman Sarcosine Is Uniquely Modulated by Aging and Dietary Restriction in Rodents and Humans Cell Reports |
author_facet |
Ryan O. Walters Esperanza Arias Antonio Diaz Emmanuel S. Burgos Fangxia Guan Simoni Tiano Kai Mao Cara L. Green Yungping Qiu Hardik Shah Donghai Wang Adam D. Hudgins Tahmineh Tabrizian Valeria Tosti David Shechter Luigi Fontana Irwin J. Kurland Nir Barzilai Ana Maria Cuervo Daniel E.L. Promislow Derek M. Huffman |
author_sort |
Ryan O. Walters |
title |
Sarcosine Is Uniquely Modulated by Aging and Dietary Restriction in Rodents and Humans |
title_short |
Sarcosine Is Uniquely Modulated by Aging and Dietary Restriction in Rodents and Humans |
title_full |
Sarcosine Is Uniquely Modulated by Aging and Dietary Restriction in Rodents and Humans |
title_fullStr |
Sarcosine Is Uniquely Modulated by Aging and Dietary Restriction in Rodents and Humans |
title_full_unstemmed |
Sarcosine Is Uniquely Modulated by Aging and Dietary Restriction in Rodents and Humans |
title_sort |
sarcosine is uniquely modulated by aging and dietary restriction in rodents and humans |
publisher |
Elsevier |
series |
Cell Reports |
issn |
2211-1247 |
publishDate |
2018-10-01 |
description |
Summary: A hallmark of aging is a decline in metabolic homeostasis, which is attenuated by dietary restriction (DR). However, the interaction of aging and DR with the metabolome is not well understood. We report that DR is a stronger modulator of the rat metabolome than age in plasma and tissues. A comparative metabolomic screen in rodents and humans identified circulating sarcosine as being similarly reduced with aging and increased by DR, while sarcosine is also elevated in long-lived Ames dwarf mice. Pathway analysis in aged sarcosine-replete rats identify this biogenic amine as an integral node in the metabolome network. Finally, we show that sarcosine can activate autophagy in cultured cells and enhances autophagic flux in vivo, suggesting a potential role in autophagy induction by DR. Thus, these data identify circulating sarcosine as a biomarker of aging and DR in mammalians and may contribute to age-related alterations in the metabolome and in proteostasis. : In a comparative metabolic screen of rodents and humans, Walters et al. show that circulating sarcosine is similarly reduced with aging and increased by dietary restriction. They demonstrate that sarcosine activates macroautophagy in cultured cells and in vivo, suggesting a role in improved proteostasis via dietary restriction. Keywords: sarcosine, aging, metabolomics, dietary restriction, autophagy, GNMT, glycerophospholipids, amino acids, glycine, methionine |
url |
http://www.sciencedirect.com/science/article/pii/S2211124718315250 |
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doaj-d0b812ca5b9349d5909aebb22098bc5a2020-11-24T21:34:58ZengElsevierCell Reports2211-12472018-10-01253663676.e6Sarcosine Is Uniquely Modulated by Aging and Dietary Restriction in Rodents and HumansRyan O. Walters0Esperanza Arias1Antonio Diaz2Emmanuel S. Burgos3Fangxia Guan4Simoni Tiano5Kai Mao6Cara L. Green7Yungping Qiu8Hardik Shah9Donghai Wang10Adam D. Hudgins11Tahmineh Tabrizian12Valeria Tosti13David Shechter14Luigi Fontana15Irwin J. Kurland16Nir Barzilai17Ana Maria Cuervo18Daniel E.L. Promislow19Derek M. Huffman20Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY, USA; Department of Medicine, Albert Einstein College of Medicine, Bronx, NY, USA; Institute for Aging Research, Albert Einstein College of Medicine, Bronx, NY, USADepartment of Medicine, Albert Einstein College of Medicine, Bronx, NY, USA; Institute for Aging Research, Albert Einstein College of Medicine, Bronx, NY, USADepartment of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY, USA; Institute for Aging Research, Albert Einstein College of Medicine, Bronx, NY, USADepartment of Biochemistry, Albert Einstein College of Medicine, Bronx, NY, USADepartment of Medicine, Albert Einstein College of Medicine, Bronx, NY, USA; Institute for Aging Research, Albert Einstein College of Medicine, Bronx, NY, USADepartment of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY, USA; Institute for Aging Research, Albert Einstein College of Medicine, Bronx, NY, USADepartment of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY, USA; Department of Medicine, Albert Einstein College of Medicine, Bronx, NY, USA; Institute for Aging Research, Albert Einstein College of Medicine, Bronx, NY, USAInstitute of Biological and Environmental Sciences, University of Aberdeen, Aberdeen, Scotland, UKDepartment of Medicine, Albert Einstein College of Medicine, Bronx, NY, USA; Einstein-Mount Sinai Diabetes Research Center, Stable Isotope and Metabolomics Core Facility, Albert Einstein College of Medicine, Bronx, New York, USADepartment of Medicine, Albert Einstein College of Medicine, Bronx, NY, USA; Einstein-Mount Sinai Diabetes Research Center, Stable Isotope and Metabolomics Core Facility, Albert Einstein College of Medicine, Bronx, New York, USADepartment of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY, USA; Institute for Aging Research, Albert Einstein College of Medicine, Bronx, NY, USADepartment of Genetics, Albert Einstein College of Medicine, Bronx, NY, USADepartment of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY, USA; Institute for Aging Research, Albert Einstein College of Medicine, Bronx, NY, USADepartment of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USADepartment of Biochemistry, Albert Einstein College of Medicine, Bronx, NY, USACharles Perkins Centre, The University of Sydney, NSW 2006, Australia; Central Clinical School, The University of Sydney, NSW 2006, Australia; Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Clinical and Experimental Sciences, Brescia University Medical School, Brescia, ItalyDepartment of Medicine, Albert Einstein College of Medicine, Bronx, NY, USA; Einstein-Mount Sinai Diabetes Research Center, Stable Isotope and Metabolomics Core Facility, Albert Einstein College of Medicine, Bronx, New York, USADepartment of Medicine, Albert Einstein College of Medicine, Bronx, NY, USA; Department of Genetics, Albert Einstein College of Medicine, Bronx, NY, USA; Institute for Aging Research, Albert Einstein College of Medicine, Bronx, NY, USADepartment of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY, USA; Institute for Aging Research, Albert Einstein College of Medicine, Bronx, NY, USADepartment of Pathology, University of Washington, Seattle, WA, USA; Department of Biology, University of Washington, Seattle, WA, USADepartment of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY, USA; Department of Medicine, Albert Einstein College of Medicine, Bronx, NY, USA; Institute for Aging Research, Albert Einstein College of Medicine, Bronx, NY, USA; Corresponding authorSummary: A hallmark of aging is a decline in metabolic homeostasis, which is attenuated by dietary restriction (DR). However, the interaction of aging and DR with the metabolome is not well understood. We report that DR is a stronger modulator of the rat metabolome than age in plasma and tissues. A comparative metabolomic screen in rodents and humans identified circulating sarcosine as being similarly reduced with aging and increased by DR, while sarcosine is also elevated in long-lived Ames dwarf mice. Pathway analysis in aged sarcosine-replete rats identify this biogenic amine as an integral node in the metabolome network. Finally, we show that sarcosine can activate autophagy in cultured cells and enhances autophagic flux in vivo, suggesting a potential role in autophagy induction by DR. Thus, these data identify circulating sarcosine as a biomarker of aging and DR in mammalians and may contribute to age-related alterations in the metabolome and in proteostasis. : In a comparative metabolic screen of rodents and humans, Walters et al. show that circulating sarcosine is similarly reduced with aging and increased by dietary restriction. They demonstrate that sarcosine activates macroautophagy in cultured cells and in vivo, suggesting a role in improved proteostasis via dietary restriction. Keywords: sarcosine, aging, metabolomics, dietary restriction, autophagy, GNMT, glycerophospholipids, amino acids, glycine, methioninehttp://www.sciencedirect.com/science/article/pii/S2211124718315250 |